全胸腔镜联合腹腔镜辅助治疗食管癌根治术的临床效果观察

Clinical effect observation of total thoracoscopic combined with laparoscopic adjuvant therapy for radical resection of esophageal cancer

目的 探讨全胸腔镜联合腹腔镜辅助治疗食管癌根治术的临床效果。方法 2019年6月至2022年6月于我院行食管癌治疗的99例患者,根据治疗方式不同分为对照组44例及研究组45例,对照组采用开放食管癌根治术,研究组采用全胸腔镜联合腹腔镜辅助食管癌根治术。对比两组手术相关指标、炎症因子水平及不良反应。结果 对照组手术时间、首次排气时间和平均住院时间显著长于研究组(P<0.05);研究组术中出血量、术后引流量少于对照组(P<0.05);治疗后,两组C反应蛋白、肿瘤坏死因子-α及白细胞介素-6水平均下降,且研究组低于对照组(P<0.05);研究组并发症发生率13.31%,明显低于对照组31.82%(P>0.05)。结论 食管癌患者采用全胸腔镜联合腹腔镜辅助食管癌根治术治疗,可以提高临床疗效且安全性较高,具有临床推广价值。

Objective To investigate the curative effect of total thoracoscopic combined with laparoscopic assisted radical resection of esophageal cancer.Methods Ninety-nine patients who received esophageal cancer treatment in our hospital from June 2019 to June 2022 were selected.According to the treatment methods,they were divided into a control group(n=44)and a study group(n=45).The control group received open radical resection of esophageal cancer,and the study group received total thoracoscopic combined with laparoscopic assisted radical resection of esophageal cancer.Operation-related indexes,inflammatory factors and adverse reactions were compared between the two groups.Results Operation time,first exhaust time and mean hospital stay in the control group were significantly longer than those in the study group(P<0.05).The intraoperative blood loss and postoperative drainage volume of the study group were less than those of the control group(P<0.05).After treatment,the levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in both groups were decreased,and the levels of CRP,TNF-αand IL-6 in the study group were lower than those in the control group(P<0.05).The complication rate of the study group was 13.31%,that was significantly lower than 31.82%of the control group(P>0.05).Conclusions Total thoracoscopic combined with laparoscopic assisted radical resection of esophageal cancer can improve the clinical efficacy.Its safety is higher.It has the value of clinical promotion.