基于数据挖掘探讨唐蜀华教授从瘀热辨治胸痹气阴两虚证的用药规律

Medication Rule in Syndrome Differentiation Based Treatment of Chest Obstruction with Deficiency of Qi-Yin from Stagnant Heat by Professor Tang Shuhua:an Analysis Based on Data Mining Techniques

目的:采用数据挖掘的方式分析唐蜀华教授辨治胸痹气阴两虚证的用药规律,归纳唐蜀华教授临床诊疗思路,以期传承其经验及学术思想。方法:收集胸痹气阴两虚证病人的中药处方资料,采用Microsoft Excel、SPSS Modeler 14.1等软件进行药物频次、归经、四气五味等数据分析,完成关联规则、聚类分析及复杂网络展示。结果:整理中药处方共135首,涉及中药164种,总使用频次达2034次,其中丹参、麦冬、五味子、川芎、刺五加、赤芍、红花等药物使用频次最多;药物性味方面,以甘味、苦味为主,辛味次之;多用寒、温之品,平药次之;药物功效方面,补虚、活血化瘀、清热并重;归肝、肺经居多;分析关联规则得出,丹参-麦冬、麦冬-五味子、五味子-丹参药物组合出现频数最高;聚类分析可得出新处方4个。结论:唐蜀华教授辨治胸痹气阴两虚证以“补”“通”“清”立法,益气养阴以扶正,活血化瘀兼清热,虚实并重,治病求于本,充分体现中医整体观辨证思想,临床收效显著。

Objective:To investigate medication rule in syndrome differentiation based treatment of chest obstruction with deficiency of Q-i Yin from stagnant heat by Professor Tang Shuhua,summarize clinical diagnosis and treatment ideas in order to inherit experience and academic ideology.Methods:Prescription data of traditional Chinese medicine(TCM)for chest obstruction patients with deficiency of Q-i Yin were collected.Microsoft Excel,and SPSS Modeler 14.1 were used to analyze the data of drug frequency,meridian tropism,and four properties and five tastes,and complete association rules,cluster analysis,and complex network display.Results:A total of 135 TCM prescriptions were sorted out,involving 164 TCM drugs with a total frequency of 2034,and Salvia miltiorrhiza,Ophiopogon japonicus,Schisandra chinensis,Rhizoma Chuanxiong,Acanthopanax senticosus,Paeoniae Radix Rubra,and Safflower were the most frequently used.In terms of Chinese herbal flavor,predominantly bitter,sweet were in properties,followed by pungent.Cold and warm drugs were more used druys,followed by flat drugs.In terms of drug efficacy,it showed equal attention to tonifying deficiency,promoting blood circulation to remove blood stasis and clearing heat,and most drugs entered the liver and lung meridians.According to the analysis of association rules,the frequency of drug combinations of Salvia miltiorrhiza-Ophiopogon japonicus,Ophiopogon japonicus-Schisandra chinensis,Schisandra chinensis-Salvia miltiorrhiza were the highest,and 4 new drug prescriptions were obtained by cluster analysis.Conclusion:Professor Tang Shuhua treated the syndrome of deficiency of Q-i Yin of chest obstruction by tonifying,dredging,and clearing legislation,invigorating Qi and nourishing Yin to support upright,activating blood circulation and removing blood stasis and clearing heat,paying equal attention to deficiency and reality,fully reflecting the thought of syndrome differentiation of TCM as a whole,and achieving remarkable clinical results.