代谢在心衰和心肌细胞再生中的作用

Role of metabolism in heart failure and cardiomyocyte regeneration

心力衰竭是各种心脏疾病的严重和终末阶段,心脏移植是目前根治严重心力衰竭的唯一疗法。由于心脏移植的复杂性和并发症,并不适用于大多数人。因此研究心肌细胞再生的新方法对心衰的治疗具有巨大的潜力。目前自然界中已发现的具备心脏再生能力的生物有斑马鱼、新生小鼠及蝾螈,这为我们研究心肌细胞再生机制提供了模型。本文列举了心脏代谢包括脂肪酸氧化、葡萄糖和氨基酸代谢、三羧酸循环代谢物的主要研究进展,并讨论了可能在心肌细胞发育和再生过程中发挥重要作用的关键代谢靶点,以期从心肌细胞再生的角度为成人心衰治疗提供新思路。

Heart failure is the severe and terminal stage of various heart diseases and heart transplantation is currently the only cure for patients with severe heart failure.Owing to the complexities and complications associated with heart transplantation,it is not suitable for most people.Thus,identifying novel approaches toward regenerating the cardiomyocytes has enormous therapeutic potential for heart failure.At present,zebrafish,neonatal mice and salamanders have been found in nature with the ability to regenerate the cardiomyocytes,which provides us with a model to study the mechanism of cardiac regeneration.This article lists major research advances in cardiometabolism,including fatty acid oxidation,glucose metabolism,amino acid metabolism and TCA cycle metabolites,and discusses key metabolic targets that may play important roles in cardiomyocyte development and regeneration,which can provide new ideas for the treatment of adult heart failure from the perspective of cardiac regeneration.