Facile Fabrication of Polymeric Ionic Liquid Grafted Porous Polymer Monolith for Mixed-Mode High Performance Liquid Chromatography

A novel polymeric ionic liquid grafted porous polymer monolith has been facilely fabricated for mixed-mode chromatography.The column is prepared from poly(glycidyl methacrylate-co-ethylene dimethacrylate)monolith through hydrolyzation of the epoxy moieties into hydroxyl groups,followed by“grafting from”polymerization of ionic liquid of 1-vinyl-3-butylimidazolium chloride.Successful modification is characterized by scanning electron microscope,infrared spectroscopy,elemental analysis and mercury intrusion porosimetry.The HPLC performance of developed column is evaluated by separating acidic vitamin B analytes,neutral steroids and basic aromatic amines in mixed-mode chromatography on a single column,respectively.The ionic liquid affords the monolith with both enhanced separation ability and improved column efficiency.