摘要
An efficient nucleophilic difluoro(phenylsulfonimidoyl)methylation of unactivated primary alkyl bromides with PhSO(NTBS)CF_(2)H has been developed.It is particularly remarkable that,when 1.5 equiv.of alkyl bromides are used,the substitution products are obtained in moderate to excellent yields.The prepared difluoro(phenylsulfonimidoyl)methylated alkanes can be readily transformed to gem-difluoroalkenes via base-mediatedβ-elimination reaction.
基金
Support of our work by the National Basic Research Program of China(Nos.2012CB215500 and 2012CB821600)
the NNSFC(No.21372246)
Shanghai QMX program(No.13QH1402400)
the Chinese Academy of Sciences is gratefully acknowledged.
