摘要
Chiral molecules containing sulfonyl and 1,5-diol moieties are useful synthetic blocks for various asymmetric transformations.A protocol has been developed for the enantioselective synthesis of optically active bis(β-hydroxy)sulfones catalyzed by a chiral cationic ruthenium diamine catalyst.A series of bis(β-hydroxy)sulfones have been obtained in excellent yields(up to 99%)with excellent enantioselectivities(up to 99%)as well as good diastereoselectivities(up to 99∶1).
基金
the National Natural Science Foundation of China(No.21272166)
the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions(No.13KJA150004)
the Program for New Century Excellent Talents in University(No.NCET-12-0743).