摘要
目的 确定头颅MRI指导的rt-PA静脉溶栓后脑出血的危险因素。方法 收集rt-PA静脉溶栓患者临床数据,分析出血组和未出血组诸因素有无统计学差异。结果 与未出血组相比,头颅MRI指导的静脉溶栓后出血组溶栓前NIHSS、溶栓合并取栓、发病至溶栓时间>4.5h,P<0.05。而多因素回归分析发现重度脑梗死(NIHSS≥21分)、溶栓合并取栓是头颅MRI指导的静脉溶栓患者脑出血的独立危险因素。结论 头颅MRI指导的rt-PA静脉溶栓后脑出血的独立危险因素为重度脑卒中(NIHSS≥21分)和溶栓合并取栓,而与其他因素无关。
Objective To identify the risk factors of intracerebral hemorrhage resulting from rt-PA intravenous thrombolysis guided by cerebral magnetic resonance imaging(MRI).Methods The clinical data of patients treated with rt-PA intravenous thrombolysis guided by cerebral MRI were consecutively collected,to analyze whether there were any difference between the intracerebral hemorrhage group and non-intracerebral hemorrhage group.Results Compared with non-intracerebral hemorrhage group,Baseline NIHSS,thrombolysis combined with thrombectomy and time of onset to thrombolysis4.5h,P 0.05.Multivariate Logistic analysis revealed that severe cerebral infarction(NIHSS≥21)and thrombolysis combined with thrombectomy were the independent risk factors of intracerebral hemorrhage resulting from intravenous thrombolysis guided by cerebral MRI.Conclusion Severe cerebral infarction(NIHSS≥21)and thrombolysis combined with thrombectomy were the independent risk factors of intracerebral hemorrhage resulting from intravenous thrombolysis guided by cerebral MRI.While other factors were not associated with it.
作者
李敏
魏丽
王玲玲
李锦师
陆练军
沈健
白青科
赵晓晖
Li Min;Wei Li;Wang Lingling;Li Jinshi;Lu Lianjun;Shen Jian;Bai Qingke;Zhao Xiaohui(Department of Neurology,the Shanghai Pudong New Area People's Hospital,Shanghai 201200,China)
出处
《脑与神经疾病杂志》
CAS
2023年第8期517-521,共5页
Journal of Brain and Nervous Diseases
基金
上海市浦东新区卫生健康委员会卫生科技项目(PW2021A-60)。
关键词
头颅MRI
静脉溶栓
急性脑梗死
脑出血
危险因素
Cerebral MRI
Intravenous thrombolysis
Acute cerebral infarction
Intracranial hemorrhage
Risk factor