C1q肿瘤坏死因子相关蛋白家族在脓毒症中的作用及机制

The role and mechanism of Clq/tumor necrosis factor related protein family in sepsis

Clq肿瘤坏死因子相关蛋白(CTRPs)是一类新发现的蛋白超家族,组织分布广泛,生物学功能多样,参与糖脂代谢调节、血管内皮细胞功能以及炎症反应等。关于CTRP家族与脓毒症的关系报道较少,少数研究显示部分CTRP家族成员参与脓毒症的发生发展。本文将介绍CTRP家族在脓毒症中的作用及具体机制。

Clq/tumor necrosis factor related proteins(CTRPs)are a newly discovered superfamily of proteins with wide tissue distribution and diverse biological functions,which are involved in the regulation of glucose and lipid metabolism,vascular endothelial cell function and inflammatory response.There are few studies on the relationship between CTRP family and sepsis,and a few studies have shown that some CTRP family members are involved in the occurrence and development of sepsis.This review introduced the role of CTRP family in sepsis and related mechanism.