鼠疫噬菌体及其受体研究进展

Research progress of Yersinia pestis phage and their receptors

鼠疫噬菌体(Yersinia pestis phage)是一种寄生于鼠疫耶尔森菌(鼠疫菌)内,且能特异性裂解鼠疫菌的病毒。受体结合蛋白(receptor binding protein,RBP)是噬菌体侵染宿主菌的吸附位点,包括细胞外膜蛋白、脂多糖、磷壁酸、菌毛、鞭毛、荚膜多糖等。其中细胞外膜蛋白和脂多糖是鼠疫噬菌体的受体。RBP在鼠疫噬菌体侵染鼠疫菌的过程中起决定性作用。因此,总结和分析鼠疫噬菌体分类、鼠疫噬菌体受体鉴定及结构的研究进展,有助于从分子层面了解鼠疫噬菌体的裂解机制及与鼠疫菌的相互作用方式,为深入研究鼠疫噬菌体受体提供帮助。

Yersinia pestis phage is a virus that is parasitic within Yersinia pestis and can specifically lyses Yersinia pestis.The adsorption sites of phage infesting host bacteria are called receptor binding protein(RBP),including extracellular membrane protein,lipopolysaccharide,teichoteic acid,pili,flagella,capsular polysaccharide,etc.,of which extracellular membrane protein and lipopolysaccharide are the receptors of Yersinia pestis phage.RBP plays a decisive role in the process of Yersinia pestis phage infecting Yersinia pestis.Therefore,the classification,isolation and application of Yersinia pestis phage are summarized;the research progress in identification and structure of Yersinia pestis phage receptor is analyzed,which is helpful in understanding the cleavage mechanism of Yersinia pestis phage and the interaction mode with Yersinia pestis from the molecular level,and provide more powerful support for in-depth study on Yersinia pestis phage receptor.