深圳市坪山区成年人心脏代谢指数、脂质聚集指数与高血压患病的关联研究

Association of cardiometabolic index and lipid accumulation product with hypertension prevalence in adults in Pingshan District,Shenzhen

目的 探索心脏代谢指数(cardiometabolic index, CMI)和脂质聚集指数(lipid accumulation product, LAP)与深圳市坪山区成年人高血压患病的关联,并评估CMI、LAP对高血压患病的预测价值。方法 采用横断面调查方法,随机抽取1 000名坪山区18~69岁常住居民作为研究对象,使用问卷调查、身体测量和血液检测收集数据,使用logistic回归模型分析CMI、LAP与高血压患病的关联。结果 共987名研究对象的有效数据纳入分析,其中男性471人(47.72%),女性516人(52.28%),平均年龄40.9±11.1岁。将不同性别研究对象按CMI和LAP的四分位数分为Q1~Q4组,男性和女性的高血压患病率均随着CMI和LAP水平上升而升高(P for trend<0.001)。logistic回归结果表明,在调整了年龄、职业等变量之后,CMI每升高一个标准差,男性、女性患高血压的OR值分别为1.251(1.025~1.526),1.685(1.001~2.836);以CMI分组Q1为对照,男性Q4组患高血压的OR值为3.519(1.343~9.222)。LAP每升高一个标准差,男性、女性患高血压的OR值分别为1.355(1.089~1.686),1.825(1.023~3.254);以LAP分组Q1为对照,男性Q3、Q4组患高血压的OR值为2.554(1.103~5.909)和5.322(2.393~11.834),女性Q4组患高血压的OR值为2.906(1.096~7.703)。ROC分析发现,CMI、LAP和BMI的曲线下面积(AUC)男性分别为0.671、0.704和0.702,女性分别为0.660、0.722和0.697,不同性别LAP的AUC均大于CMI(P<0.01)。结论 深圳市坪山区成年人CMI和LAP值越大,高血压患病率越高,CMI和LAP在预测高血压患病上具有一定价值。

Objective To explore the association of(cardiometabolic index,CMI)and(lipid accumulation product,LAP)with the prevalence of hypertension in adults in Pingshan District,Shenzhen,and to evaluate the predictive value of CMI and LAP for the prevalence of hypertension.Methods A cross-sectional survey was conducted,in which 1000 permanent residents aged 18-69 years in Pingshan District,Shenzhen were randomly selected as survey subjects.The data were collected using questionnaires,physical measurements and blood tests,and the relationship between CMI,LAP and hypertension prevalence was analyzed using logistic regression models.Results A total of 987 subjects were included in the analysis,including 471(47.72%)males and 516(52.28%)females,with an average age of 40.9±11.1 years.Subjects of different genders were divided into groups Q1 to Q4 according to quartiles of CMI and LAP,and the prevalence of hypertension increased with increasing levels of CMI and LAP in both men and women(P for trend<0.001).Logistic regression analysis revealed that after adjusting for variables such as age and occupation,the OR for hypertension was 1.251(1.025-1.526)and 1.685(1.001-2.836)for men and women,respectively,for each standard deviation increase in CMI;the OR for hypertension was 3.519(1.343-9.222)for men in the Q4 group,compared to the CMI subgroup Q1.For each standard deviation increase in LAP,the ORs for hypertension were 1.355(1.089-1.686)and 1.825(1.023-3.254)for men and women,respectively;compared to LAP subgroup Q1,the ORs for hypertension in the male Q3 and Q4 groups were 2.554(1.103-5.909)and 5.322(2.393-11.834),while the OR for hypertension in the female Q4 group was 2.906(1.096-7.703).ROC analysis revealed that the area under the curve(AUC)for CMI,LAP,and BMI was 0.671,0.704,and 0.702 for males,and 0.660,0.722,and 0.697 for females,respectively.The AUC for LAP was greater than that for CMI for different genders(P<0.01).Conclusion The greater the CMI and LAP values in adults in Pingshan District,Shenzhen,the higher the prevalence of hypertension.CMI and LAP have certain values in predicting the prevalence of hypertension.