针灸联合中药对骨质疏松症患者骨代谢、骨密度及免疫功能的影响

Investigation of the effect of acupuncture combined with Chinese herbal medicines on bone metabolism,bone mineral density and immune function in patients with osteoporosis

目的观察针灸联合补肾健脾活血方对骨质疏松症患者骨代谢、骨密度(bone mineral density,BMD)及免疫功能的影响。方法将80例肾虚血瘀型骨质疏松症患者随机分为对照组和研究组,每组40例。对照组采取补肾健脾活血方治疗,研究组在对照组基础上联合针灸治疗。观察两组治疗前后BMD、骨代谢参数、中医证候积分变化,并比较两组不良反应。结果治疗后,两组BMD均升高(P<0.05),骨碱性磷酸酶(bone alkaline phosphatase,BAP)、骨钙素(osteocalcin,OC)水平升高(P<0.05),Ⅰ型胶原交联氨基端肽(N-telopeptide of typeⅠcollagen,NTXI)水平下降(P<0.05),CD4^(+)T细胞、CD4^(+)/CD8^(+)水平均升高(P<0.05),CD8^(+)T细胞水平降低(P<0.05),中医证候积分均降低(P<0.05);且研究组上述指标均优于对照组(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论针灸联合补肾健脾活血方治疗骨质疏松症,可改善患者骨代谢、BMD和中医证候积分,增强免疫功能。

Objective To observe the effect of acupuncture and moxibustion combined with Bushen Jianpi Huoxue recipe on bone metabolism,bone mineral density(BMD)and immune function in patients with osteoporosis.Method A total of 80 patients with osteoporosis of kidney deficiency and blood stasis patten were randomly divided into the a control group and a study group,with 40 cases in each group.The control group was treated with Bushen Jianpi Huoxue recipe,and the study group was treated with acupuncture and moxibustion in addition to the treatment used in the control group.The changes of BMD,bone metabolism parameters and TCM syndrome score were observed before and after treatment,and the adverse reactions were compared between the two groups.Result After treatment,BMD increased in both groups(P<0.05),bone alkaline phosphatase(BAP)and osteocalcin(OC)levels increased(P<0.05),and N-telopeptide of typeⅠcollagen(NTXI)levels decreased(P<0.05),CD4^(+)T cell and CD4^(+)/CD8^(+)levels increased(P<0.05),CD8^(+)T cell level decreased(P<0.05),and Chinese medicine syndrome points decreased(P<0.05);and the above indexes in the study group were better than those in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Acupuncture and moxibustion combined with Bushen Jianpi Huoxue recipe in the treatment of osteoporosis can improve bone metabolism,BMD and TCM syndrome score,and enhance immune function.