2002至2021年间免疫逃逸领域相关研究的文献计量学和可视化分析

A bibliometric and visualization analysis of immune escape from 2002 to 2021

目的:通过文献计量学分析免疫逃逸领域的相关文献,探讨该领域的发展现状、研究热点和研究前沿,从而为科研人员和临床工作者提供指导。方法:检索Web of Science Core Collection(WoSCC)中自2002至2021年间与免疫逃逸相关的文献,采用Microsoft Excel 2020,CiteSpace V和VOSviewer等软件对纳入文献中提取的信息进行可视化分析并生成网络图。结果:2002至2021年间WoSCC共收录免疫逃逸相关文献634篇,发文数量整体上呈现逐年上升的趋势;发文量最多的国家和机构分别是中国(214,33.75%)和哈佛大学(39,6.15%);对该领域贡献最大的研究者是来自澳大利亚的KENT(10,2.76%);J Immunol是发表该领域相关论文最多的期刊(24,3.78%);癌症、免疫治疗和感染是近些年来免疫逃逸相关领域的研究热点;免疫治疗、细胞、基因以及抗原等关键词是目前该领域的研究前沿。结论:免疫逃逸相关领域正迅速发展,我国对此做出了卓越的贡献。该领域目前的研究热点主要集中于癌症和感染性疾病的免疫治疗,细胞、免疫治疗、基因和抗原等话题是目前的研究前沿,也将是该领域未来的发展趋势。

Objective:To explore the development status,research hotspots and research frontiers of immune escape by bibliometrics,so as to provide guidance for researchers and clinical workers.Methods:Web of Science Core Collection(WoSCC)literature related to immune escape from 2002 to 2021 was searched,using Microsoft Excel 2020,Software such as CiteSpace V and VOSviewer visually to analyze the information extracted from the included literature and generate network maps.Results:A total of 634 articles related to immune escape were collected in WoSCC from 2002 to 2021,and the number of articles showed an increasing trend year by year.The largest published country and institution is China(214,33.75%)and Harvard University(39,6.15%).The researcher who contributed the most to this field was KENT from Australia(10,2.76%).J Immunol published the largest number of papers in this field(24,3.78%).Cancer,immunotherapy and infection are the research hotspots of immune escape in recent years.Immunotherapy,cell,gene and antigen are the current research frontiers in this field.Conclusion:Research on immune escape is currently booming,and China has made remarkable contributions to this field.The current research hotspot in this field mainly focuses on the immunotherapy for cancer and infectious diseases,and the topics such as cell,immunotherapy,gene and antigen are the current research frontier,and will also be the future development trend in this field.