高频超声鉴别侵袭性与非侵袭性皮肤基底细胞癌的应用价值

High-frequency Ultrasound Differentiates Aggressive from Non-aggressive Cutaneous Basal Cell Carcinomas

目的 探讨高频超声鉴别侵袭性与非侵袭性皮肤基底细胞癌(BCC)的应用价值。方法 分析经病理确诊的95例皮肤BCC患者的病理切片,进一步对其病理亚型进行划分,根据病理亚型的侵袭性将患者分为侵袭性和非侵袭性,比较侵袭性和非侵袭性超声征象的差异,无相关性分析结果。结果 在BCC的超声征象中,侵袭性BCC比非侵袭性更容易浸润至皮下组织(χ^(2)=5.189,P=0.023),病灶内部更容易出现液性暗区(χ^(2)=10.672,P=0.001);而在病灶形态、最大直径、平均高回声点计数、后方回声变化以及Alder血流分级方面,侵袭性与非侵袭性BCC间差异无统计学意义。结论 侵袭性与非侵袭性皮肤BCC的高频超声表现间有一定差异,这些差异或许能在术前鉴别二者及制定治疗方案中发挥主要作用。

Objective In order to examine the value of high-frequency ultrasound in differential diagnosis of aggressive and non-aggressive cutaneous basal cell carcinoma(BCC).Methods The pathological sections of 95 patients with BCCs were analyzed to further classify their pathological subtypes.According to the aggressiveness of pathological subtypes,patients were categorized into aggressive and non-aggressive BCCs,and the differences of aggressive and non-aggressive ultrasonographic features were compared.No correlation analysis results were found.Results Among all ultrasonographic features,aggressive BCCs tended to infiltrate into the sub-cutaneous tissue when compared with non-aggressive lesions(χ^(2)=5.189,P=0.023).And the cystic regions were more often seen in aggressive BCCs than in non-aggressive BCCs(χ^(2)=10.672,P=0.001).There were no significant differences in margin,maximum diameter,mean hyperechoic spots count,posterior echo or blood flow of Alder grade.Conclusion The ultrasonographic features of aggressive and non-aggressive cutaneous BCC are different.These differences may be useful in preoperative assessments and specific surgical planning.