支气管扩张治疗中多索茶碱联合小剂量罗红霉素对患者肺功能、排痰量及生活质量的影响

Effects of doxofylline combined with low-dose roxithromycin on pulmonary function,sputum output and quality of life in bronchiectasis patients

目的研究支气管扩张治疗中多索茶碱联合小剂量罗红霉素对患者肺功能、排痰量及生活质量的影响.方法观察对象为2022年1月-2023年1月入院的80例支气管扩张患者,随机分为对照组(40例)与研究组(40例),对照组行小剂量罗红霉素治疗,研究组行多索茶碱联合小剂量罗红霉素治疗;比较两组治疗前后肺功能指标[呼气流量峰值(PEF)、用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、FEV1/FVC]、24h排痰量、生活质量(SF-36)评分与治疗后总有效率、不良反应(头晕、腹泻腹痛、恶心呕吐)发生率.结果两组治疗前PEF、FVC、FEV1、FEV1/FVC、24h排痰量、SF-36评分差异无显著差异(P>0.05);两组治疗后PEF、FVC、FEV1、FEV1/FVC、SF-36评分明显高于治疗前,24h排痰量明显低于治疗前,差异显著(P<0.05);研究组治疗后PEF、FVC、FEV1、FEV1/FVC、SF-36评分、总有效率明显高于对照组,24h排痰量明显低于对照组,差异显著(P<0.05);两组治疗后头晕、腹泻腹痛、恶心呕吐发生率差异不显著(P>0.05).结论支气管扩张治疗中应用多索茶碱联合小剂量罗红霉素的效果显著,可明显改善患者肺功能并降低排痰量,还可以提高其生活质量,且不良反应少,安全性高.

Objective To study the effect of doxofylline combined with low dose roxithromycin on pulmonary function,sputum output and quality of life in patients with bronchiectasis.Methods The subjects were 80 patients with bronchiectasis from January 2022 to January 2023.They were randomly divided into control group(n=40)and study group(n=40).The control group was treated with low dose of roxithromycin,the study group was treated with doxofylline combined with low-dose roxithromycin;the pulmonary function indexes[peak expiratory flow(PEF),forced vital capacity(FVC),forced expiratory volume in one second(FEV1),FEV1/FVC],sputum output in 24 hours,quality of life(SF-36)scores before and after treatment were compared between the two group.The the total effective rate and the incidence of adverse reactions(dizziness,diarrhea,abdominal pain,nausea and vomiting)after treatment were also compared.Results There was no significant difference in PEF,FVC,FEV1,FEV1/FVC,24-hour sputum output and SF-36 between the two groups before treatment(P>0.05),but the PEF,FVC,FEV1,FEV1/FVC and SF-36 scores in the two groups after treatment were significantly higher than those before treatment(P<0.05);after treatment,the PEF,FVC,FEV1,FEV1/FVC,SF-36 scores and total effective rate in the study group were significantly higher than those in the control group,and the sputum output in 24 hours was significantly lower than those in the control group(P<0.05);there was no significant difference in the incidence of dizziness,diarrhea,abdominal pain,nausea and vomiting between the two groups after treatment(P>0.05).Conclusion Doxofylline combined with low-dose roxithromycin bronchiectasis is effective in improving pulmonary function,reducing sputum production and improving the quality of life.