重复经颅磁刺激联合氟西汀治疗老年抑郁症患者的临床效果

Clinical Effiect of Repetitive Transcranial Magnetic Stimulation Combined with Fluoxetine in the Treatment of Elderly Patients with Depression

目的:探讨重复经颅磁刺激联合氟西汀治疗老年抑郁症患者的临床效果。方法:选取2020年5月—2021年5月广东省江门市第三人民医院收治的老年抑郁症患者100例为研究对象,按照电脑随机法分为对照组(采用氟西汀治疗)和试验组(在对照组基础上联合重复经颅磁刺激治疗),各50例。比较两组患者24项汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、简易智能精神状态量表(MMSE)和不良反应量表(TESS)评分情况。结果:治疗后,两组HAMD、HAMA评分均下降,试验组低于对照组,差异有统计学意义(P<0.001);两组MMSE评分均升高,试验组高于对照组,差异有统计学意义(P<0.001);试验组食欲减退、头痛、便秘评分低于对照组,差异有统计学意义(P<0.001)。结论:重复经颅磁刺激联合氟西汀治疗老年抑郁症患者的临床效果显著,可有效改善患者的病情,调节其焦虑、抑郁情绪,提高认知能力。

Objective:To explore the clinical efficacy of repetitive transcranial magnetic stimulation combined with fluoxetine in the treatment of elderly patients with depression.Methods:A total of 100 elderly patients with depression were selected at the Third People's Hospital of Jiangmen City,Guangdong Province from May 2020 to May 2021,and they were randomly divided into control group(treated with fluoxetine)and the experimental group(treated with repetitive transcranial magnetic stimulation on the basis of the control group)according to the computer random method,with 50 cases in each group.The 24-item Hamilton Depression Scale(HAMD),Hamilton Anxiety Scale(HAMA),Mini-Mental State Examination(MMSE)and Adverse Effects Scale(TESS)scores were compared between the two groups.Results:After treatment,the HAMD and HAMA scores of the two groups were decreased,and the experimental group was lower than the control group,the difference was statistically significant(P<0.001);the MMSE scores of the two groups were all increased,and the experimental group was higher than the control group,the difference was statistically significant was statistically significant(P<0.001);The scores of The scores of anorexia,headache and constipation in the experimental group were lower than those in the control group,and the difference was statistically significant(P<0.001).Conclusion:Repetitive transcranial magnetic stimulation combined with fluoxetine has a significant clinical effect in the treatment of elderly patients with depression.It can effectively improve the patient's condition,regulate anxiety and depression,and improve cognitive ability.