重复经颅磁刺激治疗小儿癫痫的基础与临床研究进展

The basis and clinical research progress of repetitive transcranial magnetic stimulation in the treatment of pediatric epilepsy

癫痫是一种常见的神经系统疾病,目前认为此类疾病主要由于神经元突发性异常放电所致的大脑短暂性功能障碍。重复经颅磁刺激(rTMS)是基于经颅磁刺激技术发展起来的一种调控大脑皮质兴奋性的神经电生理技术,具有无痛无创、安全性好、不良反应小等优点。并且rTMS已广泛应用于实验研究和临床治疗,对中枢神经系统疾病的治疗具有较好的疗效,对儿童癫痫的检测、治疗具有重要价值。现就rTMS在儿童癫痫治疗过程中的原理、作用机制、应用及安全性方面进行综述。

Epilepsy is a common neurological disease,which is caused by transient brain dysfunction due to sudden abnormal discharges of neurons.Repetitive transcranial magnetic stimulation(rTMS)is a neuroelectrophysiological technique developed based on transcranial magnetic stimulation that regulates the excitability of the cerebral cortex,presenting the advantages of painless,non-invasiveness,good safety and less adverse events.In addition,rTMS is widely used in experimental research and clinical treatment,which has a high efficacy on the treatment of central nervous system diseases,and important value for the detection and treatment of pediatric epilepsy.This paper reviews the principle,mechanism,application and safety of rTMS in the treatment of pediatric epilepsy.