食管鳞状细胞癌脑转移危险因素分析

Analysis of risk factors for brain metastasis in patients with esophageal squamous cell carcinoma

目的:探讨食管鳞状细胞癌(食管鳞癌)脑转移的危险因素。方法:回顾性分析来自省部共建食管癌防治国家重点实验室食管/贲门癌临床诊疗、病理和随访信息数据库中46例食管癌脑转移术后患者的资料,采用倾向性评分匹配法选取46例未发生脑转移的食管鳞癌患者;比较两组的临床病理特征,使用条件Logistic回归分析筛选食管鳞癌脑转移的危险因素。结果:与非脑转移组比较,食管鳞癌脑转移组低分化患者比例较大,淋巴结转移阳性率较高(P<0.05)。条件Logistic回归分析结果显示,淋巴结转移阳性是食管鳞癌脑转移的危险因素,OR(95%CI)为11.086(1.286~95.557)。结论:淋巴结转移阳性是食管鳞癌脑转移的危险因素。

Aim:To explore the risk factors of brain metastasis in esophageal squamous cell carcinoma(ESCC).Methods :Retrospective analysis was made on 46 ESCC patients with brain metastasis after ESCC surgery from the database established by the State Key Laboratory of Esophageal Cancer Prevention and Treatment,which included the clinical treatment,pathological diagnosis and follow-up information of esophagus and gastric cardia cancers.Totally 46 ESCC patients without brain metastasis were selected as control using propensity score matching method.The clinicopathological characteristics between the 2 groups were compared,and conditional Logistic regression analysis was used to screen risk factors for brain metastasis of ESCC. Results :Compared with the non-brain metastasis group,the proportion of poorly differentiated patients and the positive rate of lymph node metastasis in the brain metastasis group were higher( P <0.05). The results of conditional Logistic regression analysis showed that lymph node metastasis was a risk factor for brain metastasis,with OR(95%CI) of 11.086(1.286-95.557). Conclusion :Lymph node metastasis may be a risk factor for brain metastasis of ESCC.