血管生成素样蛋白4在肿瘤发生发展中的作用

Role of ANGPTL4 in tumorigenesis and development

血管生成素样蛋白4(ANGPTL4)参与调控糖脂代谢、血管生成等,与肿瘤的发生发展、侵袭转移密切相关。ANGPTL4基因的异常表达可促进或抑制肿瘤细胞的生长、增殖,在肿瘤的发生发展中发挥促癌或抑癌作用。探讨ANGPTL4基因在不同癌种发生发展中的作用,可为其成为评估肿瘤诊断、预后和疗效的指标提供参考。

Angiopoietin-like protein 4(ANGPTL4)is involved in the regulation of glucose and lipid metabolism and angiogenesis,and is closely related to tumorigenesis,development,invasion and metastasis.The abnormal expression of ANGPTL4 gene can promote or inhibit the growth and proliferation of tumor cells and play a tumor-promoting or anti-tumor role in the occurrence and development of tumors.To explore the role of ANGPTL4 gene in the occurrence and development of different tumors can provide reference for evaluating the diagnosis,prognosis and curative effect of tumors.