基于肠道菌群及炎性微环境探讨子宫内膜异位症湿瘀互结病机的内涵

Study on the Biological Connotation of Endometriosis with Intermingling Dampness and Blood Stasis Syndrome Based on Intestinal Flora and Inflammatory Microenvironment

子宫内膜异位症(EMs)是一种雌激素依赖的慢性炎症性疾病,免疫炎症反应是其关键环节,湿瘀互结是EMs的重要病机,免疫炎性微环境是湿瘀状态的体现,脾病是湿瘀状态发生的基础,肠道菌群的稳态与脾的生理功能密切相关,故在中医学“脾病,脉道不利”的理论指导下,探讨肠道菌群及炎性微环境与EMs的关系,将有助于从“肠道菌群-湿瘀互结”的新视角阐明EMs的发病机制。故以肠道菌群为靶点,重新建立内稳态,可成为预防和治疗EMs的新思路。

Endometriosis(EMs)is a chronic inflammatory disease of estrogen dependence,and immune inflammatory reaction is an important step.Intermingling dampness and blood stasis syndrome is the important pathogenesis in EMs.Inflammatory microenvironment is closely connected with intermingling dampness and blood stasis state.Pi disease is the precondition of dampness and blood stasis state.The homeostasis of gut microbiota is the functional connotation of Pi.Therefore,the relationships between gut microbiota-inflammatory microenvironment and EMs were studied under the guidance of the theories of"Pi disease,adverse pulse tract"in traditional Chinese medicine,which will be helpful to clarify the mechanism for EMs occurrence from the new perspective of"gut microbiota dampness and blood stasis interminglink".At the same time,the gut microbiota as a target to re-establish homeostasis can be a new direction for the prevention and treatment of EMs.