摘要
2022年WHO在线(https://tumourclassification.iarc.who.int/home/)发布了第五版儿童肿瘤分类,外周神经母细胞性肿瘤(peripheral neuroblastic tumours,pNTs)作为独立章节被介绍。本次儿童肿瘤分类新增免疫组织化学对节细胞神经瘤与节细胞神经母细胞瘤的鉴别作用,细化pNTs的形态特征,强调形态学对遗传变异以及预后的提示意义、MYC家族蛋白表达较基因扩增更强的指示价值等。本文结合相关文献,对第五版WHO儿童肿瘤分类pNTs做简要介绍,以期为病理医生和临床医生提供新的诊疗帮助。
In 2022,WHO promulgated the 5th edition of Classification of Paediatric Tumours.Peripheral neuroblastic tumours(pNTs)were discussed as a separate chapter.Paediatric Tumours Classification incorporated the effect of immunohistochemistry for differentiating ganglioneuroma from ganglioneuroblastoma,refined the morphological characteristics of pNTs and stressed the significance of morphology for genetic variation and prognosis and greater indicative value of MYC family protein expression than gene amplification,etc.This review focused upon pNTs in the 5th edition of WHO Classification of Paediatric Tumours based upon the relevant literature.It was intended to bring novel perspectives and deeper insights to pathologists and clinicians.
作者
方园
董岿然
陈莲
Fang Yuan;Dong Kuiran;Chen Lian(Department of Pathology,Anhui Provincial Children's Hospital,Children's Hospital of Fudan University,Hefei 230051,China;Department of Surgery,Children's Hospital of Fudan University,Shanghai 201102,China;Department of Pathology,Children's Hospital of Fudan University,Shanghai 201102,China)
出处
《中华小儿外科杂志》
CSCD
北大核心
2023年第8期764-768,共5页
Chinese Journal of Pediatric Surgery
基金
安徽医科大学校科研基金(2021xkj109)。
