摘要
食管鳞状细胞癌(ESCC)是最常见的恶性肿瘤之一,预后较差。4-硝基喹啉-1-氧化物(4NQO)是一种水溶性的喹啉衍生物,在体内可以成功诱导鳞状上皮细胞癌的产生。建立并优化4NQO诱导小鼠ESCC形成的实验方法可以为ESCC研究提供更适宜的原位模型。
Esophageal squamous cell carcinoma(ESCC)is one of the most common malignant tumors with a poor prognosis.4-nitroquinoline-1-oxide(4NQO)is a water-soluble quinoline derivative that can successfully induce the production of squamous cell carcinoma in vivo.Establishing and optimizing experimental methods for 4NQO induced ESCC formation in mice can provide a more suitable in situ model for the study of ESCC.
作者
李金歌
李晶
张振悍
郭建鑫
王景普
吴忠冰
Li Jinge;Li Jing;Zhang Zhenhan;Guo Jianxin;Wang Jingpu;Wu Zhongbing(School of Integrated Chinese and Western Medicine,Hebei Medical University,Shijiazhuang 050017,China;Department of Traditional Chinese Medicine,The Fourth Hospital of Hebei Medical University,Shijiazhuang 050019,China;Basic Research Office of Traditional Chinese Medicine,School of Integrated Chinese and Western Medicine,Hebei Medical University,Shijiazhuang 050017,China)
出处
《国际肿瘤学杂志》
CAS
2023年第7期437-441,共5页
Journal of International Oncology
基金
国家自然科学基金(82274593)
河北医科大学2022年大学生创新性实验计划(USIP2022079)。
关键词
4-硝基喹啉-1-氧化物
食道鳞癌
原位模型
4-nitroquinoline-1-oxide
Esophageal squamous cell carcinoma
In situ model
