乙肝相关性原发性肝癌患者血清AFP、TSGF、AFU、GGT及CEA联合诊断研究

Study on the combined diagnosis of SERUM AFP,TSGF,AFU,GGT and CEA in patients with hepatitis B associated primary liver cancer

[目的]研究乙肝相关性原发性肝癌患者血清甲胎蛋白(AFP)、恶性肿瘤特异生长因子(TSGF)、α-L-岩藻糖苷酶(AFU)、γ-谷氨酰转移酶(GGT)及癌胚抗原(CEA)联合诊断效能,以期为临床诊治提供参考。[方法]将182例乙肝相关性原发性肝癌患者的临床资料设为研究组,另选取同期收治的160例乙肝相关肝硬化患者设为对照组。所有患者均空腹抽取外周静脉血,GGT、AFU采用速率法检测,TSGF采用酶联免疫吸附法测定,CEA、AFP采用化学发光免疫法测定,并对比2组患者相关检验效能。[结果]研究组血清AFP、TSGF、AFU、GGT及CEA含量高于对照组,差异均有统计学意义(P<0.05);Ⅲ/Ⅳ期血清AFP、TSGF、AFU、GGT及CEA水平高于Ⅰ/Ⅱ期,低分化患者上述血清指标高于中/高分化,且差异均有统计学意义(P<0.05)。诊断效能对比AFP、TSGF、AFU、GGT及CEA联合诊断的灵敏度及特异度高于各单项诊断。[结论]乙肝相关性原发性肝癌患者血清AFP、TSGF、AFU、GGT及CEA含量明显升高,且分期越晚,分化越低,含量越高,联合诊断特异度及灵敏度更高,值得临床借鉴。

[Objective]To study the combined diagnostic efficacy of serum alpha-fetoprotein(AFP),tumor specific growth factor(TSGF),α-L-fucosylase(AFU),γ-glutamyltransferase(GGT)and carcinoembryonic antigen(CEA)in patients with hepatitis B associated primary hepatic cancer(PHC),so as to provide reference for clinical diagnosis and treatment.[Methods]The clinical data of 182 patients with hepatitis B associated primary liver cancer were set as the study group,and 160 patients with hepatitis B associated cirrhosis were selected as the control group.Peripheral venous blood was collected on fasting state in all the three groups,GGT and AFU were detected by rate method,TSGF was detected by enzyme-linked immunosorption method,CEA and AFP were detected by chemiluminescence immunoassay,and the efficacy of relevant tests was compared between the two groups.[Results]The contents of AFP,TSGF,AFU,GGT and CEA in the study group were higher than those in the control group,with statistical significance(P<0.05).Compared among the different subgroups,serum AFP,TSGF,AFU,GGT and CEA levels in stage Ⅲ/Ⅳ were higher than those in stage Ⅰ/Ⅱ,and the serum indexes in low-differentiation patients were higher than those in medium-high differentiation patients,and the differences were statistically significant(P<0.05).The sensitivity and specificity of AFP,TSGF,AFU,GGT and CEA combined diagnosis were higher than those of single diagnosis.[Conclusion]The levels of AFP,GGT and CEA in serum of patients with early PHC are significantly increased,and the specificity and sensitivity of combined diagnosis are higher,which is worth clinical reference.