水凝胶负载PRP治疗慢性难愈性创面的研究进展

Hydrogel-loaded PRP for the Treatment of Chronic Refractory Wounds

慢性难愈性创面是临床治疗中的一个严峻难题。尽管富血小板血浆(platelet rich plasma,PRP)治疗已被广泛证实为有效的治疗方法,但传统的PRP体外激活后在短时间内会释放全部的生长因子,并且因激活后胶体与上清液分离,富含因子的上清液容易流淌丢失,难以形成稳定的结构,影响了其治疗效果。为了克服这一问题,近年来研究人员开始探索使用水凝胶作为PRP的载体,以改善传统PRP治疗的缺陷。因此本文综述了水凝胶搭载PRP治疗慢性难愈性创面的最新研究进展,并为优化治疗方案提供了参考。

The treatment of chronic non-healing wounds remain challenging in terms of complexity.Although platelet rich plasma(PRP)therapy has been widely proven effective,the traditional method of in vitro activation of PRP leads to the rapid release of all growth factors.Due to the separation of colloid and supernatant after activation,the factorrich supernatant is easy to flow and lose,and it is difficult to form a stable structure,which affects its therapeutic effect.To overcome this problem,researchers in recent years have explored hydrogels as carriers for PRP to improve the shortcomings of traditional PRP treatment.This article reviews the latest research on hydrogel-loaded PRP for the treatment of chronic nonhealing wounds and provides a reference for optimal treatment.