椎间盘源性腰痛的发病机制与治疗进展

Research progress on the mechanism and treatment of discogenic low back pain

椎间盘退变(intervertebral disc degeneration,IDD)是腰痛(low back pain,LBP)的主要原因之一,由IDD引起的LBP被称为椎间盘源性LBP。导致IDD因素众多,本文重点探讨炎症因子调控、神经血管增生在椎间盘源性LBP形成过程中的作用,并回顾细胞、生长因子、基因等生物疗法在治疗IDD及椎间盘源性LBP的进展。

Intervertebral disc degeneration(IDD) is one of the main causes of lower back pain(LBP),while LBP caused by IDD is known as discogenic LBP.There are many factors that lead to IDD,this article focuses on the role of inflammatory factor regulation and neurovascular proliferation in the pathogenesis of disc-derived LBP,and reviews advances in cellular,growth factor,and gene biologic therapies for the treatment of IDD and discogenic LBP.