SVM预测模型在原发性肝癌病理分化程度判断中的应用

Application of SVM prediction model in judging the degree of pathological differentiation of primary hliver cancerepatocellular carcinoma

目的研究线性支持向量机(SMV)预测模型在原发性肝癌(HCC)病理分化程度判断中的应用价值。方法选择2018年6月-2020年6月在江南大学附属无锡五院确诊为HCC的患者78例。所有患者行CT纹理分析,并选取动脉期特征,采用SMV预测模型进行HCC病理分化程度判断。以术后病理检测结果作为金标准,采用Kappa检验CT纹理分析中动脉期SVM预测肿瘤分化程度的一致性进行判定。结果78例HCC患者肿瘤分化程度分别为低分化、中分化、高分化,分别占总数的25.64%、34.62%、39.74%。动脉期SVM判断HCC患者肿瘤低分化、中分化、高分化与病理检测结果比较,有较高的一致性,Kappa值分别为0.835、0.860、0.892。动脉期SVM预测HCC低分化的灵敏度为85.71%、特异度为96.49%、准确率为93.59%;预测HCC中分化的灵敏度为89.29%、特异度为96.00%、准确率为93.59%;预测HCC高分化的灵敏度为96.55%、特异度为93.88%、准确率为94.87%。结论SMV预测模型对判断HCC病理分化程度有较高价值。

Objective To study the application value of linear support vector machine(SMV)prediction model in judging the degree of pathological differentiation of primary hepatocellular carcinomaliver cancer(HCC).Methods A total of 78 patients who were diagnosed with HCC from June 2018 to June 2020 in Wuxi Fifth People's Hospital were selected.All patients underwent CT texture analysis,selected the characteristics of arterial phase,and used the SMV prediction model to judge the degree of HCC pathological differentiation.Taking postoperative pathological examination results as the gold standard,Kappa test was used to determine the consistency of the arterial phase SVM in predicting the degree of tumor differentiation in CT texture analysis.Results The degree of tumor differentiation of 78 HCC patients was poorly differentiated,moderately differentiated,and well differentiated,accounting for 25.64%,34.62%,and 39.74%of the total.The arterial phase SVM judged that the tumors of HCC patients were poorly differentiated,moderately differentiated,and highly differentiated,and the results of pathological examination were relatively consistent.The Kappa values were 0.835,0.860,and 0.892,respectively.The sensitivity,specificity and accuracy of arterial SVM in predicting HCC differentiation were 85.71%,96.49%and 93.59%,respectively.The sensitivity,specificity and accuracy of in predicting HCC differentiation were 89.29%,96.00%and 93.59%,respectively,.The sensitivity,specificity and accuracy oinf predicting high differentiation of HCC were 96.55%,93.88%and 94.87%,respectively.Conclusion The SMV prediction model has a high value in judging the degree of HCC pathological differentiation.