摘要
帕金森病(Parkinson’s disease,PD)是一个发病机制复杂、临床表现多变的神经系统退行性疾病,目前该病的早期诊断、发病机制的研究等仍存在不少挑战。近年来,正电子发射断层扫描-磁共振(positron emission tomography-magnetic resonance,PET/MR)逐渐发展,它能够将不同生理和代谢信息数据在时间和空间上进行精确配准,真正实现多模态成像,从而为PD从分子水平到临床的研究提供更加丰富的影像学依据。
Parkinson’s disease(PD)is a neurodegenerative disease with complex pathogenesis and variable clinical manifestations.However,there are still many challenges in the pathogenesis and early diagnosis.Recently,positron emission tomography⁃magnetic resonance(PET/MR)has emerged as a truly multi⁃modal imaging tool,which can precisely extract and combine physiological and metabolic information in different time and space,thereby enrich imaging basis for the research of PD from molecular level to clinical diagnosis and treatment.
作者
沈楠
高珂梦
黄家晖
唐立钧
李天女
SHEN Nan;GAO Kemeng;HUANG Jiahui;TANG Lijun;LI Tiannü(Department of Nuclear Medicine,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)
出处
《南京医科大学学报（自然科学版）》
CAS
北大核心
2023年第9期1295-1300,共6页
Journal of Nanjing Medical University(Natural Sciences)
基金
江苏省自然科学基金(KF202206)。
关键词
帕金森病
正电子发射断层扫描
磁共振成像
Parkinson’s disease
positron emission tomography
magnetic resonance imaging
