下丘脑室旁核调控心血管活动的研究进展

Research progress of hypothalamic paraventricular nucleus regulating cardiovascular activity

随着中国步入老龄化社会的进程逐渐加快,各种心血管疾病(包括慢性心力衰竭、心肌梗死和高血压等)的发病率逐年上升,目前还缺乏有效的预防手段。越来越多的研究发现,中枢神经系统与心血管生理机能的调控有密不可分的交互作用,其中下丘脑室旁核(paraventricular nucleus,PVN)中神经元和多种细胞因子参与调控心血管活动,是心血管活动的关键性调节中枢。本文旨在归纳和总结近年来PVN在调控心血管活动中作用及机制的研究进展。

With the gradual acceleration of China’s aging society,the incidence rate of various cardiovascular diseases is increasing,including chronic heart failure,myocardial infarction,and hypertension,etc.There is still a lack of effective prevention measures.More and more studies have found that the central nervous system has an inseparable interaction with the regulation of cardiovascular physiological functions.Among them,neurons and various cytokines in the paraventricular nucleus(PVN)of the hypothalamus participate in the regulation of cardiovascular activities,which is a key regulatory center for regulating cardiovascular activities.This article aims to summarize and conclude the recent research progress on the role and mechanism of PVN in regulating cardiovascular activity.