深圳市宝安地区妊娠期甲状腺功能减退患者UGT1A1基因多态性与妊娠期合并症和不良妊娠结局的关系

Correlation of UGT1A1 gene polymorphism with pregnancy complications and adverse pregnancy outcomes among gestational hypothyroidism patients in Shenzhen Bao'an area

目的分析深圳市宝安地区女性妊娠期甲状腺功能减退(简称甲减)患者尿苷二磷酸葡萄糖醛酸转移酶1A1(UGT1A1)基因多态性与妊娠期合并症和不良妊娠结局的关系。方法选取2019年4月—2021年4月深圳市宝安区石岩人民医院妊娠期甲减患者160例(研究组)和甲状腺功能正常的妊娠期女性160例(对照组)。检测所有研究对象UGT1A1基因多态性,比较研究组不同UGT1A1基因型患者妊娠期合并症(妊娠高血压、妊娠糖尿病、妊娠肝内胆汁淤积症)和不良妊娠结局(早产、胎儿宫内窘迫、新生儿窒息等)发生情况。结果研究组UGT1A1基因GG基因型分布频率(16.25%)低于对照组(51.25%)(P<0.001);GA、AA基因型分布频率(42.50%、41.25%)均高于对照组(23.75%、25.00%)(P<0.001,P<0.05)。研究组UGT1A1基因AA基因型患者妊娠高血压、妊娠糖尿病和妊娠肝内胆汁淤积症发生率分别为18.18%、21.21%、12.12%,均高于GG型(分别为0.00%、3.85%、0.00%)和GA型(分别为2.94%、4.41%、0.00%)(P<0.05)。研究组UGT1A1基因AA基因型患者不良妊娠结局总发生率为21.21%,高于GG型(0.00%)和GA型(5.88%)(P<0.05)。结论深圳市宝安地区女性妊娠期甲减患者UGT1A1基因型以GA、AA为主,其中AA基因型患者妊娠期合并症和不良妊娠结局发生风险更高。

Objective To study the relationship between uridine diphosphate-glucuronosyl-transferase 1A1(UGT1A1)gene polymorphism and pregnancy complications and adverse pregnancy outcomes in patients with gestational hypothyroidism in Shenzhen Bao'an area.Methods Totally,160 patients with gestational hypothyroidism in Shenzhen Bao'an Shiyan People's Hospital from April 2019 to April 2021 were enrolled as study group.Another 160 pregnant females with normal thyroid function were enrolled as control group.UGT1A1 gene polymorphism was determined.The pregnancy complications(hypertension,diabetes and intrahepatic cholestasis)and adverse pregnancy outcomes(preterm birth,fetal distress and neonatal asphyxia)in different UGT1A1 genotypes were compared.Results The proportion of UGT1A1 GG genotype in study group was 16.25%,which was lower than that in control group(51.25%)(P<0.001),while the proportions of GA and AA genotypes were 42.50%and 41.25%,which were higher than those in control group(23.75%and 25.00%,respectively)(P<0.001,P<0.05).In study group,the incidence rates of hypertension,diabetes and intrahepatic cholestasis in patients with AA genotype were 18.18%,21.21%and 12.12%,respectively,which were higher than those with GG genotype(0.00%,3.85%and 0.00%,respectively)and GA genotype(2.94%,4.41%and 0.00%,respectively)(P<0.05).In study group,the total incidence rate of adverse pregnancy outcomes in AA genotype was 21.21%,which was higher than those in GG genotype(0.00%)and GA genotype(5.88%)(P<0.05).Conclusions UGT1A1 genotypes of patients with gestational hypothyroidism in Shenzhen Bao'an area are mainly GA and AA,among which AA genotype patients have high risk of pregnancy complications and adverse pregnancy outcomes.