放射性心脏损伤国内相关文献分析及研究进展

Literature analysis and research progress on radiation-induced heart injury in China

目的基于中国相关文献分析放射性心脏损伤的研究现状及评述。方法利用“中国知网CNKI数据库”“万方数据库”“维普中文科技期刊数据库”“中国生物医学文献数据库”,以1983—2021年的期刊文献为资料来源,建立文献数据库。对放射性心脏损伤的文献年代、文献类型、文献杂志分布等方面进行量化分析。结果共纳入300篇文献。文献年代分布:1983—2021年间放射性心脏损伤的文献数量逐渐增多,总体呈上升趋势。文献杂志分布前3位:《中华放射肿瘤学杂志》《中华放射医学与防护杂志》《中华肿瘤防治杂志》。文献类型分布:临床研究、综述、动物实验分别占总文献的48.50%、25.58%、17.61%。临床型研究分布:以肺癌、食管癌、乳腺癌研究最多,其次是胸腺瘤、淋巴瘤。动物实验中动物模型以大鼠研究最多,实验造模选择放射剂量以20 Gy最多。结论国内对于放射性心脏损伤的研究逐渐增多。临床方面的研究多于动物实验方面,临床方面研究以胸部肿瘤居多;动物实验研究方面潜力较大,仍需要我们不断探索放射性心脏损伤的发病机制及药物预防、干预。

Objective To analyze the research status and comment of radiation-induced heart injury based on relevant literature analysis in China.Methods A literature database was established with studies published from 1983 to 2021 as the data source from"China National Knowledge Infrastructure(CNKI)database","Wanfang Database","VIP Chinese Science and Technology Journal Database"and"China Biology Medicine Disc".The publication date,type and journal distribution of studied related to radiation-induced heart injury were quantitatively analyzed.Results A total of 300 literatures were included.The chronological distribution of literatures:from 1983 to 2021,the number of literatures related to radiation-induced heart injury was gradually increased,and the overall trend was on the rise.The top three publication journals were Chinese Journal of Radiation Oncology,Chinese Journal of Radiation Medicineand Protection,and Chinese Journal of Cancer Prevention and Treatment.Literature type distribution:clinical research accounted for 48.50%,25.58%for review,and 17.61%for animal experiment,respectively.The distribution of clinical research types:lung cancer,esophageal cancer and breast cancer were the most,followed by thymoma and lymphoma.In animal experiments,rat was the most frequently studied animal model,and the maximum radiation dose was 20 Gy.Conclusions The number of studies related to radiation-induced heart injury is gradually increasing in China.The quantity of clinical studies is higher than that of animal experiments,most clinical studies focus on chest tumors,but there is great potential in animal experimental research.We still need to explore the pathogenesis of radiation-induced heart injury and develop drug prevention and intervention strategies.