辐射诱导远隔效应机制的研究进展

Research progress in the mechanism of abscopal effect induced by radiation

放疗联合免疫疗法治疗肿瘤可以诱发更强的远隔效应,抑制非照射野内肿瘤的生长,但临床上远隔效应的发生非常少见且不可预测,需要深入研究远隔效应复杂的分子机制。据报道,一些新的因素参与了辐射诱导远隔效应的调节,但其分子机制还未被充分描述。本文就巨噬细胞、肿瘤引流淋巴结、p53和外泌体参与的远隔效应机制进行综述,为开发更有效的肿瘤放疗方法提供理论基础。

Radiotherapy combined with immunotherapy for the treatment of cancer can induce stronger abscopal effect(AE)and inhibit the growth of tumors outside of radiation field,but the occurrence of AE is distinctly uncommon and unpredictable in clinical practice.The complex molecular mechanism underlying AE remains to be in-depth understood.It has been reported that some new factors are involved in the regulation of AE induced by radiation,but the molecular mechanism has not been fully unravelled.In this article,the roles of macrophages,tumor draining lymph node,p53 and exosomes in the new mechanisms of AE were reviewed,aiming to provide a theoretical basis for the development of more effective cancer therapeutics.