针对性干预对应用输液港行新辅助化疗的乳腺癌患者发生静脉血栓栓塞的影响

Effect of targeted intervention on venous thromboembolism in breast cancer patient receiving neoadjuvant chemotherapy via the infusion port

目的探讨针对性干预对应用输液港行新辅助化疗的乳腺癌患者发生静脉血栓栓塞(VTE)的影响。方法收集2021年11月至2022年10月于徐州医科大学附属连云港医院住院治疗的123例乳腺癌患者的临床资料,根据住院期间是否接受了针对VTE的干预措施将患者分为干预组(n=67)和对照组(n=56)。所有患者于住院期间均植入输液港,并通过输液港进行规范的新辅助化疗。比较两组患者的临床分期、手术时生理状态、乳腺癌部位、手术方式、放疗情况、住院期间VTE及其他并发症的发生情况。结果两组患者的临床分期、手术时生理状态、乳腺癌部位、手术方式、放疗情况比较,差异均无统计学意义(P>0.05)。住院期间,干预组患者VTE的发生率低于对照组患者,差异有统计学意义(P<0.05)。住院期间,干预组患者除VTE以外的其他并发症的发生率为26.9%(18/67),对照组患者除VTE以外的其他并发症的发生率为16.1%(9/56),两组比较,差异无统计学意义(P>0.05)。结论针对性干预可以有效、安全地降低应用输液港行新辅助化疗的乳腺癌患者发生VTE的风险,值得临床推广。

Objective To investigate the effect of targeted intervention on venous thromboembolism(VTE)in breast cancer patient receiving neoadjuvant chemotherapy via the infusion port.Method The clinical data of 123 patients with breast cancer hospitalized in Lianyungang Hospital Affiliated to Xuzhou Medical University from November 2021 to October 2022 were collected,patients were divided into intervention group(n=67)and control group(n=56)according to whether they received interventions for VTE during hospitalization.All patients were implanted with an infusion port during hospitalization,and received standardized neoadjuvant chemotherapy via the infusion port.The clinical stage,menstrual status,breast cancer location,surgical method,radiotherapy,incidence of VTE and other complications during hospitalization were compared between the two groups.Result There was no significant difference in the clinical stage,physiological state during surgery,breast cancer location,surgical method,and radiotherapy between the two groups(P>0.05).During hospitalization,the incidence rate of VTE in the intervention group was lower than that in the control group,and the difference was statistically significant(P<0.05).During hospitalization,the incidence rate of complications other than VTE was 26.9%(18/67)in the intervention group,and 16.1%(9/56)in the control group,there was no significant difference between the two groups(P>0.05).Conclusion Targeted intervention could effectively and safely reduce the risk of VTE in breast cancer patients receiving neoadjuvant chemotherapy with an infusion port,and it is worthy of clinical promotion.