小檗碱抗妇科肿瘤作用机制的研究进展

Research advance on mechanism of berberine against gynecology cancer

妇科肿瘤严重威胁女性的生命健康,目前妇科肿瘤的治疗仍以手术和放疗为主,并使用化疗药预防复发和转移。小檗碱为季铵生物碱,具有广泛的生物活性。小檗碱能够抑制肿瘤细胞生长、增殖,抑制肿瘤细胞迁移、侵袭,诱导肿瘤细胞凋亡,并增加化疗药敏感性。总结了小檗碱抗乳腺癌、卵巢癌、宫颈癌、子宫内膜癌等妇科肿瘤作用机制的研究进展,以期将小檗碱开发为防治妇科肿瘤的新药提供参考。

Gynecological tumors pose a serious threat to women's lives and health.At present,the treatment of gynecological tumors is still mainly surgery and radiotherapy,and chemotherapy drugs are used to prevent recurrence and metastasis.Berberine is a quaternary ammonium alkaloid with a wide range of pharmacological activities.Berberine can inhibit the growth and proliferation of tumor cells,inhibit the migration and invasion of tumor cell migration,induce apoptosis of tumor cells,and increase the sensitivity of chemotherapy drugs.This article summarized the research progress on mechanism of berberine against gynecological tumors,such as breast carcinoma,ovarian carcinoma,cervical carcinoma,endometrial carcinoma,etc.,in order to provide reference for the development of berberine as a new drug for the prevention and treatment of gynecological tumors.