基于“脾-线粒体相关”探讨线粒体功能异常与盆腔器官脱垂的关系

Study on the Relationship Between Mitochondrial Dysfunction and Pelvic Organ Prolapse Based on“Spleen Mitochondria Correlation”

盆腔器官脱垂是由于盆底肌肉和筋膜组织异常造成的盆腔器官下降而引发的器官位置异常及功能障碍。盆底结构老化是造成该病的重要原因之一,脾虚是其常见中医证候,而线粒体在衰老及脾虚证的发生中具有重要作用。前人提出“脾-线粒体相关”理论,认为线粒体是中医脾的分子生物学基础,文章基于此理论特对线粒体功能异常与盆腔器官脱垂的关系进行分析,旨在为今后临床学者在盆腔器官脱垂发病机制的研究上提供新思路,同时为临床诊治工作提供参考。

Pelvic organ prolapse(POP)refers to the abnormal position and dysfunction of organs caused by pelvic organ decline caused by abnormal pelvic floor muscles and fascia tissue.The aging of pelvic floor structure is one of the important causes of POP.Spleen deficiency is a common traditional Chinese medical syndrome of POP,and mitochondria play an important role in aging and the occurrence of spleen deficiency syndrome.The“spleen-mitochondria correlation”theory was proposed by predecessors,who believed that mitochondria was the molecular biological basis of spleen in traditional Chinese medicine.Based on this theory,this paper analyzed the relationship between mitochondrial dysfunction and pelvic organ prolapse,aiming to provide a new idea for future clinical scholars to study the pathogenesis of pelvic organ prolapse,and also provide a reference for clinical diagnosis and treatment.