微量营养素在炎症性肠病中的作用

Role of micronutrients in inflammatory bowel disease

炎症性肠病(inflammatory bowel disease,IBD)是一种自身免疫性肠道疾病,分为克罗恩病(Crohn's disease,CD)、溃疡性结肠炎(ulcerative colitis,UC)和病理学不能确定的未定型结肠炎.由于饮食限制和肠道吸收不良,IBD患者常面临营养不良的风险,如微量营养素缺乏.微量营养素包括维生素和矿物质,在人体新陈代谢和维持组织功能方面起着重要作用.本文综述了微量营养素在IBD中的作用,发现微量营养素可以通过调节免疫、肠道菌群、氧化应激、肠道屏障功能等多方面影响IBD的疾病病程.监测IBD患者的微量营养素水平并及时补充对延缓疾病进展、改善临床症状至关重要.

Inflammatory bowel disease(IBD)is an autoimmune intestinal disease that includes ulcerative colitis,Crohn’s disease,and indeterminate colitis.Patients with IBD are often at risk for malnutrition,including micronutrient deficiencies,due to dietary restrictions and poor intestinal absorption.Micronutrients,including vitamins and minerals,play an important role in the human body’s metabolism and maintenance of tissue functions.This article reviews the role of micronutrients in IBD.Micronutrients can affect the occurrence and progression of IBD by regulating immunity,intestinal flora,oxidative stress,intestinal barrier function,and other aspects.Monitoring and timely supplementation of micronutrients are important to delay progression and improve clinical symptoms in IBD patients.