间歇性气囊加压联合华法林、低相对分子质量肝素对产后静脉血栓栓塞症高危患者凝血功能、血小板活化功能的影响

Effects of intermittent balloon compression combined with warfarin and low molecular weight heparin on coagulation function and platelet activation function in high-risk patients with postpartum venous thromboembolism

目的探讨间歇性气囊加压联合华法林、低相对分子质量肝素对产后静脉血栓栓塞症高危患者凝血功能、血小板活化功能的影响。方法选取2019年8月至2021年8月我院收治的100例产后静脉血栓栓塞症高危患者为研究对象,以随机数字表法将其分为对照组和观察组,各50例。对照组采用华法林联合低相对分子质量肝素治疗,观察组在对照组基础上联合间歇性气囊加压治疗。比较两组的临床效果。结果治疗后,观察组的血栓调节蛋白(TM)、凝血酶-抗凝血酶复合物(TAT)及组织型纤溶酶原激活物-抑制剂复合物(t-PAIC)水平低于对照组(P<0.05)。治疗后,观察组的血小板α颗粒膜蛋白-140(GMP-140)水平及血小板最大聚集率(MAR)低于对照组(P<0.05)。治疗后,观察组的巨噬细胞炎性蛋白-1α(MIP-1α)水平及D-二聚体与纤维蛋白原比值(DFR)低于对照组(P<0.05)。观察组的静脉血栓栓塞症总发生率低于对照组(P<0.05)。结论间歇性气囊加压联合华法林、低相对分子质量肝素对产后静脉血栓栓塞症有较好的预防效果,可改善凝血功能、血小板活化功能。

Objective To investigate the effects of intermittent balloon compression combined with warfarin and low molecular weight heparin on coagulation function and platelet activation function in high-risk patients with postpartum venous thromboembolism.Methods A total of 100 high-risk patients with postpartum venous thromboembolism admitted in our hospital from August 2019 to August 2021 were selected as the research objects.The patients were divided into control group and observation group by random number table method,with 50 cases in each group.The control group was treated with warfarin combined with low molecular weight heparin,and the observation group was treated with intermittent balloon compression on the basis of the control group.The clinical effects of the two groups were compared.Results After treatment,the levels of thrombomodulin(TM),thrombin-antithrombin complex(TAT)and tissue plasminogen activator inhibitor complex(t-PAIC)in the observation group were lower than those in the control group(P<0.05).After treatment,the platelet alpha granule membrane protein-140(GMP-140)level and maximum platelet aggregation rate(MAR)in the observation group were lower than those in the control group(P<0.05).After treatment,the macrophage inflammatory protein-1α(MIP-1α)level and D-dimer to fibrinogen ratio(DFR)in the observation group were lower than those in the control group(P<0.05).The total incidence of venous thromboembolism in the observation group was lower than that in the control group(P<0.05).Conclusion Intermittent balloon compression combined with warfarin and low molecular weight heparin has a good preventive effect on postpartum venous thromboembolism,which can improve coagulation function and platelet activation function.