血清可溶性髓样细胞触发受体2与脑小血管病的相关性研究

Correlation between serum soluble triggering receptor expressed on myeloid cells 2 and cerebral small vessel disease

目的:探讨血清可溶性髓样细胞触发受体2(sTREM2)与脑小血管病(CSVD)影像学总负荷及其认知功能的相关性。方法:选取CSVD病人86例为观察组,同期具有脑血管病危险因素、头颅MRI结果阴性的门诊就诊病人70例为对照组。ELISA检测2组间sTREM2及白细胞介素6(IL-6)水平。观察组根据CSVD影像学总负荷评分分为轻度组(0~1分)、中度组(2分)和重度组(3~4分)3个亚组,简易精神状态检查量表(MMSE)评估观察组的认知功能水平。比较sTREM2与IL-6水平、CSVD影像学总负荷及MMSE评分的相关性。结果:观察组sTREM2和IL-6水平较对照组升高,MMSE评分较对照组降低(P<0.01)。观察组中度组和重度组sTREM2和IL-6水平高于轻度组,重度组高于中度组(P<0.01),观察组中度组和重度组MMSE评分低于轻度组,重度组低于中度组(P<0.01)。观察组sTREM2水平与IL-6水平呈正相关关系,与MMSE评分均呈负相关关系(r=0.842,-0.526,P<0.01)。以CSVD为因变量,以sTREM2、IL-6、年龄、高血压、糖尿病、低密度脂蛋白等为自变量进行logistic多因素回归分析,结果显示sTREM2、年龄及高血压是CSVD的危险因素。结论:sTREM2在CSVD病人外周血中表达增高,且与其认知功能损害呈正相关关系。sTREM2、年龄及高血压病是CSVD的危险因素。

Objective:To investigate the correlation between serum soluble triggering receptor expressed on myeloid cells 2(sTREM2)and total imaging load and cognitive function in cerebral small vessel disease(CSVD).Methods:A total of 86 patients with CSVD were selected as the observation group,and 70 outpatients with cerebrovascular disease risk factors and negative head MRI results were selected as the control group.Serum levels of sTREM2 and interleukin-6(IL-6)were measured by ELISA.The observation group was divided into mild group(0-1 point),moderate group(2 point)and severe group(3-4 point)according to the total CSVD imaging load score.The Mini-mental state examination(MMSE)was used to evaluate the cognitive function level of the observation group.The correlation between sTREM2 and IL-6 level,total imaging burden of CSVD and MMSE score was compared.Results:Serum levels of sTREM2 and IL-6 in the observation group were higher than those in the control group,and MMSE scores were lower than those in the control group(P<0.01).The levels of sTREM2 and IL-6 in moderate group and severe group were higher than those in the mild group,and those in the severe group were higher than those in the moderate group(P<0.01).The MMSE scores of the moderate group and severe group were lower than those of the mild group,and those of the severe group were lower than those of the moderate group(P<0.01).In the observation group,sTREM2 level was positively correlated with IL-6 level,and negatively correlated with MMSE score(r=0.842,r=-0.526,P<0.01).With CSVD as the dependent variable and sTREM2,IL-6,age,hypertension,diabetes,low density lipoprotein and MMSE as the independent variables,logistic regression analysis showed that sTREM2,age and hypertension were the risk factors for CSVD.Conclusions:The expression of sTREM2 in peripheral blood of CSVD patients is increased,and it is positively correlated with cognitive impairment.The higher the total imaging load of CSVD,the more significant the increase of sTREM2.STREM2,age and hypertension are risk factors for CSVD.