中医药治疗后循环缺血性眩晕疗效与安全性的Meta分析

A meta-analysis of efficacy and safety in the treatment of circulatory is chemic vertigo after traditional Chinese medicine

目的:系统评价中医药治疗后循环缺血性眩晕的疗效与安全性。方法:检索收集中医药治疗后循环缺血性眩晕的随机对照试验(RCT),在中国学术期刊网络出版总库(CNKI)、中国生物医学文献数据库(CBM)、维普中文科技期刊数据库(VIP)、万方数据知识服务平台、中国临床试验注册中心数据库5个数据库中进行中文文献的检索,在PubMed、Cochrane Library、Embase、Web of Science、Clinical Trials 5个数据库中进行英文文献的检索。检索时间为从各数据库建库起至2022年1月1日。完成文献筛选后使用改良后的Jadad评分量表及Cochrane偏倚风险工具进行质量评价,采用Review Manager 5.4软件进行发表偏倚图的制作,使用STATA 15.0软件对纳入文献的临床总有效率、不良反应发生率及临床复发率进行Meta分析。结果:共纳入9项RCT研究,共954例病人,Meta分析结果显示:中医药治疗的临床总有效率比西医治疗高,差异有统计学意义[RR=1.20,95%CI(1.13,1.27),P=0.000<0.05];不良反应及临床复发率因相关纳入研究较少无法进行Meta分析。结论:目前的证据表明,中医药治疗后循环缺血性眩晕可取得较好的临床疗效。

Objective:To systematically evaluate the efficacy and safety of traditional Chinese medicine in the treatment of postcirculation ischemic vertigo.How:Randomized controlled trials(RCTS)of circulatory ischemic vertigo after traditional Chinese medicine were collected.Chinese literature was searched in five databases:China Academic Journal Network Publication Database(CNKI),China Biomedical Literature Database(CBM),VIP Chinese Science and Technology Journal Database(VIP),Wanfang Data Knowledge Service Platform,and China Clinical Trial Registry Database.English literature was searched in five databases:PubMed,Cochrane Library,Embase,Web of Science and Clinical Trials.The search period is from the establishment of each database to January 1,2022.After literature screening,the improved Jadad rating scale and Cochrane bias risk tool were used for quality evaluation.Review Manager 5.4 software was used to make publication bias chart.STATA 15.0 software was used to conduct meta-analysis of the total clinical effective rate,incidence of adverse reactions and clinical recurrence rate of the included literatures.Results:A total of 954 patients were included in 9 RCT studies.The meta-analysis results showed that the total clinical effective rate of TCM treatment was higher than that of western treatment,and the difference was statistically significant(RR=1.20,95%CI(1.13,1.27),P=0.000<0.05).Meta-analysis of adverse reactions and clinical recurrence rates was not possible due to the limited number of relevant included studies.Conclusion:The present evidence shows that the treatment of circulatory ischemic vertigo after traditional Chinese medicine can achieve better clinical effect.