摘要
Background:This study aimed to determine for the fi rst time the age-and gender-specific reference intervals for biomarkers of bone,metabolism,nutrition,and obesity in a nationally representative sample of the Iranian children and adolescents.Methods:We assessed the data of blood samples obtained from healthy Iranian children and adolescents,aged 7 to 19 years.The reference intervals of glucose,lipid profile,liver enzymes,zinc,copper,chromium,magnesium,and 25-hydroxy vitamin D[25(OH)D]were determined according to the Clinical&Laboratory Standards Institute C28-A3 guidelines.The reference intervals were partitioned using the Harris–Boyd method according to age and gender.Results:The study population consisted of 4800 school students(50%boys,mean age of 13.8 years).Twelve chemistry analyses were partitioned by age and gender,displaying the range of results between the 2.5th to 97.5th percentiles.Significant differences existed only between boys and girls at 18 to 19 years of age for low density lipoprotein-cholesterol.25(OH)D had the only reference interval that was similar to all age groups and both sexes.Conclusions:This study presented the first national database of reference intervals for a number of biochemical markers in Iranian children and adolescents.It is the fi rst report of its kind from the Middle East and North Africa.The fi ndings underscore the importance of providing reference intervals in different ethnicities and in various regions.
基金
This study was approved by the Isfahan University of Medical Sciences(No.293214).
