摘要
Objective:To observe the effects of electroacupuncture(EA)with varied frequencies on headache and anxiety-depression symptoms in patients with migraine and to screen optimal frequency of EA for patientswith such conditions.Design:Single-center,randomized,controlled clinical trial was designed,and the outcome assessors and statisticians were blinded.The patients with migraine were randomized into 2 Hz EA group,100 Hz EA group and sham-stimulation group.In each group,the changes in migraine attacks,days with headache,the scores of visual analogy scale(VAS),self-rating anxiety scale(SAS),self-rating depression scale(SDS)and migraine-specific quality-of-life questionnaire(MsQ),as well as the dosage of analgesics were observed at the baseline,during treatment,in 1,2 and 3 months of follow-up separately.Setting:Patients were enrolled in the Third Afiliated Hospital of Zhejiang Chinese Medical University,between 1st August 2018 and 31st July 2021.Participants:Sixty-five migraine patients with or without aura.Interventions:In the EA groups,the acupoints were bilateral Fengchi(GB20),Gongxue(Extra),Sizhukong(TE23),Taiyang(EX-HN5),Shuaigu(GB8),Waiguan(TE5)and Yanglingquan(GB34).Electric stimulation was exerted at GB20 and Gongxue(Extra),with 2 Hz and 100 Hz separately.In the sham-stimulation group,the shallow acupuncture was operated at the sites 1 cm lateral to GB20 and Gongxue(Extra),and on the radial side of TE5 and GB34.The output wires were cut off after attached to the acupoints.The patients in each group received the treatment 3 times weekly,once every two days,for consecutive 4 weeks.The complete intervention was composed of 12 treatments.Main outcome measures:Changes in numbers of migraine attacks at treatment phase(week 1 to week 4)from the baseline(week-4 to week 0)in patients of each group Kesults:(1)Cnangesinmigraineattacks anadays witnneaaacne:intneZ Hz EA anaIuu Hz EA groups the changes of migraine attacks and days of headache were higher significantlyywhencomparedwith that in the sham-stimulation group at the same time stage(P<0.05).There was no statistical difference between two EA groups.(2)Changes of VAS score:In the 2 Hz EA and 100 Hz EA groups,the changes of VAS score were significantly higher when compared with that in the sham-stimulation group during the treatment stage(P<0.05).There was no statistical difference between two EA groups.(3)Assessment of anxiety and depression:The differences in the changes of SAS and sDS scores had no statistical significance among the three groups at each assessment stage(P>0.05).(4)Assessment on the quality of life:Compared with the sham-stimulation group at the same time stage,the MsQ score were increased significantly during treatment in patients of the 2 Hz EA and 100 Hz EA groups(P<0.05).There was no statistical difference between two EA groups.(5)Assessment on safety and compliance:The patients of each group had sound compliance.There was no adverse events during trial,suggesting promising safety of treatment.Conclusion:EA may effectively reduce the migraine attacks,and the days and intensity of headache,presenting promising safety.However,there was no significant improvement on anxiety-depression symptoms,and no significant difference between high and low frequencies of EA treatment in relieving headache and anxiety/depression symptoms in the patients with migraine.
作者
聂娜
沈琼颖
黄睿
叶思婷
陈乐
周传龙
梁宜
Na NIE;Qiong-ying SHEN;Rui HUANG;Si-ting YE;Le CHEN;Chuan-long ZHOU;Yi LIANG(The Third Affiliated Hospital,Zhejiang Chinese Medical University,Hangzhou 310005,China;The Third Clinical Medical School,Zhejiang Chinese Medical University,Hangzhou 310053,China)
基金
Supported by the Foundation of Health Commission of Zhejiang Province:2018ZA060,2020ZB125
Scientific research project of Zhejiang Chinese Medical University:2020ZY10。
