肾虚肝郁型多囊卵巢综合征患者LncRNA SRA和鞘磷脂的表达及其对疾病的诊断意义

Expressions of LncRNA SRA and Sphingomyelin in PCOS Patients with Kidney Deficiency and Liver Depression and Their Diagnostic Significance

目的:探讨肾虚肝郁型多囊卵巢综合征(PCOS)患者与正常对照组患者的临床特征及血清LncRNA SRA和鞘磷脂(SM)水平的差异。方法:纳入30例肾虚肝郁型PCOS妇女作为病例组,30例正常的妇女作为对照组,测定临床指标和血清LncRNA SRA、SM水平,应用SPSS软件进行数据统计分析。结果:肾虚肝郁型PCOS患者T、DHEAS、GS、LncRNA SRA、SM、LH、PRL、E_(2)、AND、CHO、FAI、LH/FSH等水平明显高于对照组(P<0.05);LncRNA SRA的ROC曲线下面积(AUC)为0.733,敏感性和特异性分别为70%和73%。SM的AUC为0.691,敏感性和特异性分别为57%和80%。结论:肾虚肝郁型PCOS患者血清中LncRNA SRA和SM水平增高,LncRNA SRA和SM水平可以作为肾虚肝郁型PCOS的诊断标志物,为肾虚肝郁型PCOS疾病的诊断提供依据,同时可以为PCOS的药物治疗提供靶点。

Objective:To investigate the clinical characteristics of polycystic ovary syndrome(PCOS)patients with kidney deficiency and liver depression and the difference in serum of LncRNA SRA and sphingomyelin(SM)levels between the patients and normal controls.Methods:Thirty PCOS women with kidney deficiency and liver depression were enrolled as case group,and 30 normal women as control group.The clinical indexes and serum LncRNA SRA and SM levels were measured,and the data were statistically analyzed with SPSS software.Results:The levels of T,DHEAS,GS,LncRNA SRA,SM,LH,PRL,E2,AND,CHO,FAI,LH/FSH,etc,in PCOS group with kidney deficiency and liver depression were significantly higher than those of control group(P<0.05);The area under the ROC curve(AUC)of LncRNA SRA was 0.733,and the sensitivity was 70%and the specificity was 73%.The AUC of SM was 0.691,and the sensitivity was 57%and the specificity was 80%.Conclusion:The levels of serum LncRNA SRA and SM in PCOS patients with kidney deficiency and liver depression are increased.the levels of LncRNA SRA and SM can be used as diagnostic markers of PCOS with kidney deficiency and liver depression syndrome.This,therefore,provides a basis for the diagnosis of PCOS with the syndrome,and provides a target for the drug treatment of PCOS.