Preparation of chitosan/ alginate microcapsules by high-voltage electrostatic method

Chitosan and sodium alginate have the opposite charges;they can become a gelatin by the electrostatic attraction,High-voltage electrostatic droplet generator method was used to prepare chitosan-sodium alginate microcapsule.Multi-layer chitosan-sodium alginate microcapsule was prepared through layer-by-layer self-assembly,and the morphology was investigated.In addition,the release property of ofloxacin in microcapsules was studied by UV-Vis microscopy under different conditions such as pH value,layer number,etc.The results showed that the prepared microcapsules have a smooth surface with average particle size about 100μm.The result of controlled release indicated that the prepared microcapsules are pH-independent,and the rate of release decreased when the layer number increases.