血清Gal-3、α1-AGP、SFRP5水平与急性心肌梗死经皮冠状动脉介入治疗术后预后不良的关系

Relationship between serum levels of Gal-3,al-AGP,SFRP 5 and poor prognosis after percutaneous intervention in

目的探究血清半乳糖凝集素-3(Gal-3)、α1酸性糖蛋白(α1-AGP)、分泌型卷曲相关蛋白5(SFRP5)水平与急性心肌梗死(AMI)患者经皮冠状动脉介入治疗(PCI)术后预后结局的关系。方法回顾性选取2019年3月至2022年3月在上海交通大学医学院附属瑞金医院行PCI的AMI患者150例,根据患者术后预后结局不同将患者分为两组:对照组(n=80,未发生主要不良心血管事件,预后较好)和观察组(n=70,发生主要不良心血管事件,患者预后不良)。收集两组患者的一般临床资料,采用酶联免疫吸附试验测定治疗前后患者的血清Gal-3、SFRP5水平,全自动胶乳免疫比浊法检测患者治疗前后的α1-AGP水平,比较两组间各指标差异。采用受试者工作特征(ROC)曲线探究血清Gal-3、α1-AGP、SFRP5水平对AMI患者PCI术后发生预后不良结局预后的预测价值。结果治疗14 d后,两组Gal-3、SFRP5水平均有所提高,α1-AGP有所降低,治疗后,观察组Gal-3、α1-AGP水平分别为(8.65±1.23)ng/mL、(152.20±10.10)mg/mL,均高于对照组[(7.89±1.21)ng/mL、(134.42±10.21)mg/mL],SFRP5水平为(19.12±0.24)ng/mL,低于对照组[(23.64±0.23)ng/mL],差异均有统计学意义(P<0.05)。ROC曲线结果显示,血清Gal-3、α1-AGP、SFRP5水平预测AMI患者术后预后不良的ROC曲线下面积分别为0.751、0.894、0.964,最佳截断值分别为7.955 ng/mL、140.590 mg/mL、21.475 ng/mL。结论AMI患者采取PCI术治疗后,血清Gal-3、α1-AGP、SFRP5水平可作为检测患者预后是否良好的指标,对观察PCI术后发生预后不良结局具有一定预测价值。

Objective To investigate the relationship between serum levels of galactin-3(Gal-3),α1 acidic glycoprotein(α1-AGP),secreted crimp-associated protein 5(SFRP5)and prognosis in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods A total of 150 patients with AMI who underwent PCI in Ruijin Hospital,Shanghai Jiao Tong University School of Medicine from March 2019 to March 2022 were retrospectively selected and divided into two groups according to the different postoperative outcomes:the control group(n=80,no major adverse cardiovascular events,good prognosis)and the observation group(n=70,major adverse cardiovascular events,poor prognosis).General clinical data of the two groups of patients were collected,serum Gal-3 and SFRP5 levels of the patients before and after treatment were determined by enzyme-linked immunosorbent assay,andα1-AGP levels of the patients before and after treatment were detected by automatic latex immunoturbidimetry,and the differences in various indicators between the two groups were compared.The predictive value of serum Gal-3,α1-AGP and SFRP5 levels for poor prognosis after PCI in AMI patients were investigated by receiver operating characteristic(ROC)curve.Results After 14 days of treatment,the levels of Gal-3 and SFRP5 in both groups increased,whileα1-AGP decreased.After treatment,the levels of Gal-3 andα1-AGP in the observation group were(8.65±1.23)ng/mL and(152.20±10.10)mg/mL,respectively,which were higher than those in the control group[(7.89±1.21)ng/mL and(134.42±10.21)mg/mL],while the level of SFRP5 was(19.12±0.24)ng/mL,which was lower than that in the control group[(23.64±0.23)ng/mL],the differences were statistically significant(P<0.05).ROC curve results showed that the area under ROC curve of serum Gal-3,α1-AGP and SFRP5 levels in predicting postoperative poor prognosis of AMI patients was 0.751,0.894 and 0.964,respectively,and the optimal cut-off value was 7.955 ng/mL,140.590 mg/mL and 21.475 ng/mL,respectively.Conclusion In summary,serum Gal-3,α1-AGP and SFRP5 levels of AMI patients after PCI can be used as indicators to detect the good prognosis of patients,and have certain predictive value for observing the adverse prognosis outcome after PCI.