参附注射液治疗脓毒血症的临床效果

Clinical effect of Shenfu Injection in the treatment of sepsis

目的探讨参附注射液治疗脓毒血症的临床效果。方法选取2021年7月至2022年12月景德镇市第三人民医院收治的100例脓毒血症患者作为研究对象,按照随机数字表法分为对照组和观察组,各50例。对照组采用血必净注射液治疗,观察组采用参附注射液治疗。比较两组患者的心功能指标、肝肾功能指标、血管活性药物应用情况、感染性休克发生情况、2周内再次复苏情况、急性生理学及慢性健康状况评分系统(APACHEⅡ)评分、序贯器官衰竭评分量表(SOFA)评分。结果观察组患者治疗后的血清肌酸激酶同工酶(CK-MB)、血清心肌肌钙蛋白T(cTnT)、血清肌钙蛋白I(cTnI)、血清脑钠肽(BNP)、血清丙二醛(MDA)水平低于对照组,差异有统计学意义(P<0.05);观察组患者治疗后的血清超氧化物歧化酶(SOD)水平高于对照组,差异有统计学意义(P<0.05);观察组患者治疗后的血清血肌酐(SCr)、血清总胆红素(TBil)、血清天冬氨酸转氨酶(AST)、血清丙氨酸转氨酶(ALT)、血清尿素氮(BUN)、血清乳酸(LA)水平低于对照组,差异有统计学意义(P<0.05);观察组患者的血管活性药物应用率、感染性休克发生率、2周内再次复苏率低于对照组,差异有统计学意义(P<0.05);观察组患者治疗后的APACHEⅡ、SOFA评分低于对照组,差异有统计学意义(P<0.05)。结论在脓毒血症休克早期复苏中应用参附注射液对提高复苏成功率效果明显,有效改善循环和灌注功能,适用于早期复苏常规用药,其临床效果和安全性相对更高,值得临床推广。

Objective To explore the clinical effect of Shenfu Injection in the treatment of sepsis.Methods A total of 100 patients with sepsis admitted to the Third People's Hospital of Jingdezhen from July 2021 to December 2022 were selected as the research subjects,and they were divided into the control group and the observation group according to the random number table method,with 50 cases in each group.The control group was treated with Xuebijing Injection,while the observation group was treated with Shenfu Injection.The cardiac function indicators,liver and kidney function indicators,application of vasoactive drugs,incidence of septic shock,resuscitation within 2 weeks,acute physiology and chronic health evaluationⅡ(APACHEⅡ)scores and sequential organ failure assessment(SOFA)scores of patients of the two groups were compared.Results After treatment,the levels of serum creatine kinase-isozyme MB(CK-MB),serum cardiac troponin T(cTnT),serum cardiac troponin I(cTnI),serum brain natriuretic peptide(BNP)and serum malondialdehyde(MDA)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The level of serum superoxide dismutase(SOD)in the observation group was higher than that in the control group after treatment,and the difference was statistically significant(P<0.05).The levels of serum creatinine(SCr),serum total bilirubin(TBil),serum aspartate aminotransferase(AST),serum alanine aminotransferase(ALT),serum blood urea nitrogen(BUN)and serum lactic acid(LA)in the observation group after treatment were lower than those in the control group,and the differences were statistically significant(P<0.05).The application rate of vasoactive drugs,incidence of septic shock and resuscitation rate within 2 weeks in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The APACHEⅡand SOFA scores of the observation group patients after treatment were lower than those of the control group,and the differences were statistically significant(P<0.05).Conclusion The application of Shenfu Injection in early resuscitation of septic shock has a significant effect on improving the success rate of resuscitation,effectively improving circulation and perfusion function,and it is suitable for routine use in early resuscitation.Its clinical efficacy and safety are relatively higher,and it is worth promoting clinically.