226例甲状腺结节患者的证候要素及应证组合研究

Study on Syndrome Elements and Syndrome Combination of 226 Patients with Thyroid Nodules

目的探索甲状腺结节的证候要素及其应证组合规律。方法以226例甲状腺结节的临床数据为基础,运用因子分析和关联规则的方法,探索甲状腺结节的证候素及其应证组合规律。结果甲状腺结节的证候要素是痰湿、湿热、阳虚;甲状腺结节易出现的证型是气虚血瘀证、气滞痰阻证、气滞血瘀证、心肝阴虚证、气阴两虚证、脾虚湿盛证和湿热瘀阻证。结论通过现代数据挖掘的方法可以对中医的临床辨证和证候的客观化研究提供有效途径和参考。

Objective To explore the syndrome elements of thyroid nodules and the regularity of their combinations.Methods Based on the clinical data of 226 cases of thyroid nodules,the method of factor analysis and association rules was used to explore the syndrome elements of thyroid nodules and their combination rules.Results The syndrome elements of thyroid nodules were phlegm-dampness,dampness-heat and Yang deficiency.The most common syndromes of thyroid nodules were Qi deficiency and blood stasis syndrome,Qi stagnation and phlegm stasis syndrome,Qi stagnation and blood stasis syndrome,Yin deficiency of heart and liver syndrome,and both deficiency of Qi and Yin syndrome,spleen deficiency syndrome and dampness-heat and blood stasis syndrome.Conclusion The method of modern data mining can provide an effective way and reference for the clinical syndrome differentiation of traditional Chinese medicine and the objective research of syndrome.