肝爽颗粒治疗非酒精性脂肪肝临床研究

Clinical Observation of Ganshuang Granules(肝爽颗粒)for Nonalcoholic Fatty Liver Disease

目的观察肝爽颗粒治疗非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)的临床疗效及对患者氧化应激指标的影响。方法研究纳入2021年1月—2021年12月商丘市第五人民医院收治的101例NAFLD患者,并随机分为对照组50例和观察组51例,对照组予多烯磷脂酰胆碱胶囊,观察组加服肝爽颗粒,连续治疗12周。比较两组肥胖相关指数(BMI、WC、WHR),肝功能(ALT、AST、GCT),血脂指标(CHOL、TG、LDL-C、HDL-C)及氧化应激指标(SOD、MDA、GSH),记录治疗过程中两组患者不良反应发生情况。结果治疗后,与对照组相比,观察组BMI、WC、WHR、ALT、AST、CHOL、TG、MDA低于对照组,SOD高于对照组,差异有统计学意义(P<0.05)。两组患者均无明显不良反应出现。结论肝爽颗粒对NAFLD有较好疗效,值得临床推广。

Objective To observe the efficacy of Ganshuang granules(肝爽颗粒)on patients with nonalcoholic fatty liver disease(NAFLD),and the impacts on oxidative stress indexes.Methods From January 2021 to December 2021,101 cases with NAFLD were selected and randomly divided into control group(50 cases)and study group(51 cases)in the Fifth People’Hospital of Shangqiu.The control group received Polyene Phosphatidylcholine capsules;the study group took Ganshuang granules additionally.All treated for 12 weeks.Obesity related indexes(BMI,WC,WHR),the liver function(ALT,AST,GCT),lipid blood indexes(CHOL,TG,LDL-C,HDL-C)and oxidative stress indexes(SOD,MDA,GSH)were compared.The adverse reactions during treatment course were recorded.Results After treatment,compared with those in control group,the levels of BMI,WC,WHR,ALT,AST,CHOL,TG and MDA were lower,SOD were higher in study group(P<0.05).There was no obvious adverse reaction occurred in both groups.Conclusion Ganshuang granules are effective for patients with NAFLD,and are worthy of widely clinical use.