2020年版《中华人民共和国药典》一部收载含黄芪成方制剂分析

Analysis of Set Prescription Preparations Containing Huangqi(Astragali Radix)in 2020 Edition of Chinese Pharmacopoeia(Part One)

目的分析2020年版《中华人民共和国药典》(以下简称《中国药典》)一部中含黄芪成方制剂的收载情况,为含黄芪的研究及新制剂开发提供参考。方法查找收集2020年版《中国药典》一部中含黄芪的成方制剂,利用Excel将含黄芪的成方制剂按制剂名称、处方组成、选材、剂型、制法、常用配伍药、功效、注意事项等进行数据统计,并将其归类与分析。结果2020年版《中国药典》一部共收载222个含黄芪成方制剂,涉及178个处方;处方药味数大多为6~15味(61.26%);选材大多为黄芪(82.89%);主要剂型有颗粒剂(22.25%)、胶囊剂(21.62%)、片剂(19.37%)、丸剂(17.12%)等;主要制法为水提(45.95%)、水提醇沉(27.03%)、粉碎(15.32%)等;均为内服药;与黄芪配伍频率较高的药为当归(38.74%)、地黄(33.78%)、党参(33.33%)、甘草(31.53%)、白术(31.53%)、川芎(28.38%)、丹参(27.03%)、茯苓(25.68%)、白芍(22.97%)等;主要功效为补气(71.17%)、活血(37.39%)、补阳(25.23%)等;共有117个品种标注了用药注意事项,主要有孕妇慎用(10.36%)、孕妇禁用(6.76%)、胃肠道反应(5.41%)等。结论2020年版《中国药典》一部中含黄芪的成方制剂品种较多,剂型多样化,疗效确切、安全,制法简单,为含黄芪的研究及新制剂开发提供参考。

Objective To interpret the record of set prescription preparations containing Huangqi(Astragali Radix)in 2020 edition of Chinese Pharmacopoeia(Part one)and provide the reference for the future research and new drug development of Huangqi(Astragali Radix).Methods The excel was used to search and conduct the data statistics of the set prescription preparations containing Huangqi(Astragali Radix)in 2020 edition of Chinese Pharmacopoeia(part one),and classify and analyze the name of preparations,prescriptions,the selection of herbs,dosage form,preparation method,compatible drugs commonly used,efficacy and precautions,etc.Results In 2020 edition of Chinese Pharmacopoeia(part one),there were 222 kinds of set prescription preparations containing Huangqi(Astragali Radix),involving 178 prescriptions.The ingredients of set prescription preparations were mainly 6-15 ingredients(61.26%).Huangqi(Astragali Radix)was mainly selected(82.89%).Dosage forms were mainly granules(22.25%),capsules(21.62%),tablets(19.37%),pills(17.12%),etc.The preparation method was mainly water decoction(45.95%),water extraction-ethanol precipitation technology(27.03%),direct grinding(15.32%),etc.All the preparations were used as oral administration.The drugs that high frequency combined with Huangqi(Astragali Radix)were Danggui(Angelicae Sinensis Radix)(38.74%),Dihuang(Rehmanniae Radix)(33.78%),Dangshen(Codonopsis Radix)(33.33%),Gancao(Glycyrrhizae Radix Et Rhizoma)(31.53%),Baizhu(Atractylodis Macrocephalae Rhizoma)(31.53%),Chuanxiong(Chuanxiong Rhizoma)(28.38%),Danshen(Salviae Miltiorrhizae Radix Et Rhizoma)(27.03%),Fuling(Poria)(25.68%),Baishao(Paeoniae Radix Alba)(22.97%),etc.The main efficacy was benefiting Qi(71.17%),activating blood circulation(37.39%),benefiting Yang(25.23%),etc.A total of 117 preparations were marked medication precautions,pregnant women with caution(10.36%),Pregnant women disabled(6.76%),Gastrointestinal reaction(5.41%),etc.Conclusion In 2020 edition of Chinese Pharmacopoeia(part one),there were many varieties set prescription preparations containing Huangqi(Astragali Radix).The dosage forms are diverse and the curative effect is obvious and safe and the preparation method is simple.It provides reference for the future research and new drug development of Huangqi(Astragali Radix).