血清TRPC1 sFRP5及SIRT1对慢性心力衰竭患者预后不良的预测价值

Predictive values of serum TRPC1,sFRP5 and SIRT1 levels to poor prognosis in patients with chronic heart failure

目的探讨血清瞬时受体电位通道1(TRPC1)、分泌型卷曲相关蛋白5(sFRP5)及沉默信息调节因子1(SIRT1)对慢性心力衰竭患者预后不良的预测价值。方法将135例慢性心力衰竭患者设为研究组,选取同时期在本院体检的120例健康志愿者作为对照组,比较两组血清TRPC1、sFRP5及SIRT1水平。随访1 a统计患者预后情况,比较不同预后患者血清TRPC1、sFRP5及SIRT1水平的差异,并分析患者预后不良的影响因素。绘制受试者工作特征曲线分析血清TRPC1、sFRP5及SIRT1对慢性心力衰竭患者预后不良的预测价值。结果研究组患者血清TRPC1、sFRP5水平高于对照组,血清SIRT1水平低于对照组,差异有统计学意义(P<0.01)。慢性心力衰竭患者预后不良发生率为28.15%,预后不良患者血清TRPC1、sFRP5水平高于预后良好患者,SIRT1水平低于预后良好患者,差异有统计学意义(P<0.01)。血清TRPC1、sFRP5水平升高及心功能Ⅳ级是影响慢性心力衰竭患者预后不良的危险因素(P<0.01),血清SIRT1是其保护因素(P<0.01)。受试者工作特征曲线显示,血清TRPC1、sFRP5及SIRT1联合预测慢性心力衰竭患者预后不良的灵敏度及曲线下面积分别为97.37%、0.915,均高于单独检测(P<0.05或0.01),特异度与单独预测比较差异无统计学意义(P>0.05)。结论慢性心力衰竭患者血清TRPC1、sFRP5水平升高,血清SIRT1水平降低,三者联合对预后不良的预测效能最佳。

Objective To explore the predictive value of serum transient receptor potential channel 1(TRPC1),secretory curl associated protein 5(sFRP5)and silent information regulator 1(SIRT1)levels to predict poor prognosis in patients with chronic heart failure(CHF).Methods A total of 135 CHF patients were assigned to research group and 120 healthy subjects who underwent physical examination in our hospital at the same period to control group.Serum TRPC1,sFRP5 and SIRT1 levels were compared between two groups.They were followed up for 1 year to count patients'prognoses,differences in serum TRPC1,sFRP5 and SIRT1 levels compared among patients with different prognoses,and influencing factors of poor prognosis analyzed.Predictive values of serum TRPC1,sFRP5 and SIRT1 levels to predict poor prognosis were analyzed by charting receiver operating characteristic(ROC)curve.Results Serum TRPC1 and sFRP5 level were higher and SIRT1 lower in research than control group,differences statistically significant(P<0.01).The incidence of poor prognosis in CHF patients was 28.15%,serum TRPC1 and sFRP5 level were higher and SIRT1 lower in patients with poor than ones with good prognosis,differences statistically significant(P<0.01).Serum TRPC1 and sFRP5 elevation and cardiac function level IV were risk factors for poor prognosis in CHF patients(P<0.01)and SIRT1 was protective factor-(P<0.01).The ROC showed that the sensitivity and area under the curve of combined TRPC1,sFRP5 and SIRT1 predicting poor prognosis in CHF patients were respectively 97.37%and 0.915,which were higher than that of single detection(P<0.05 or 0.01),and differences in specificities and single detection weren't statistically significant(P>0.05).Conclusion Serum TRPC1 and sFRP5 levels of CHF patients elevate and SIRT1 lower and the combination of the three is the best predictor of poor prognosis.