m^(6)A去甲基化酶在白血病中的研究进展

Research progress of m^(6)A demethylase in leukemia

N6-甲基腺苷嘌呤甲基化是最常见的RNA化学修饰,去甲基化酶可对已经发生甲基化修饰的碱基进行去甲基化进而影响细胞mRNA的稳定性。去甲基化酶在白血病中异常高表达,通过调控下游靶基因转录本的稳定性发挥致癌作用。因此,开发靶向去甲基化酶的分子抑制剂,可为白血病的治疗提供新方向。

Methylation of m^(6)-methyladenosine purines is the most common method of RNA chemical modification,and demethylase can demethylate bases that have undergone m^(6)A methylation modification to affect the stability of cellular mRNA.Demethylase is abnormally highly expressed in leukemia and has carcinogenic effects by modulating the stability of downstream target gene transcripts.Therefore,molecular inhibitors targeting demethylase could be developed to treat leukemia,which provides a new direction for the treatment of leukemia.