欣母沛联合缩宫素治疗产后出血的效果及对患者凝血功能的影响

Effect of Hemabate Combined with Oxytocin in the Treatment of Postpartum Hemorrhage and its Effect on Coagulation Function

目的研究欣母沛联合缩宫素治疗产后出血的效果及对患者凝血功能的影响。方法选取2020年4月-2022年4月我院接诊的78例产后出血患者为研究对象,采用随机数字表法分为对照组(n=39)和观察组(n=39),对照组采用缩宫素治疗,观察组在对照组基础上联合应用欣母沛治疗,比较两组止血效果、产后不同时间出血量、止血时间、凝血功能指标[活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、凝血酶原时间(PT)]以及不良反应发生率。结果观察组止血总有效率(94.87%)高于对照组(82.05%)(P<0.05);两组产后30 min出血量比较,差异无统计学意义(P>0.05),观察组产后2、24 h出血量均小于对照组(P<0.05);观察组止血时间短于对照组(P<0.05);两组治疗后APTT、PT均小于治疗前,FIB大于治疗前,且观察组APTT、PT小于对照组,FIB大于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论欣母沛联合缩宫素治疗产后出血的效果确切,可提高止血总有效率,减少产后24 h内出血量,缩短止血时间,改善凝血功能指标,且不良反应少,具有一定的应用优势。

Objective To study the effect of hemabate combined with oxytocin in the treatment of postpartum hemorrhage and its effect on coagulation function.Methods A total of 78 patients with postpartum hemorrhage who were admitted to our hospital from April 2020 to April 2022 were selected as the research objects.They were divided into control group(n=39)and observation group(n=39)by random number table method.The control group was treated with oxytocin,and the observation group was treated with hemabate on the basis of the control group.The clinical hemostatic effect,bleeding volume at different time after delivery,hemostasis time,coagulation function indexes[activated partial thromboplastin time(APTT),fibrinogen(FIB),prothrombin time(PT)]and incidence of adverse reactions were compared between the two groups.Results The total effective rate of hemostasis in the observation group(94.87%)was higher than that in the control group(82.05%)(P<0.05).There was no significant difference in the amount of bleeding at 30 min after delivery between the two groups(P>0.05),but the amount of bleeding at 2 and 24 h after delivery in the observation group was smaller than that in the control group(P<0.05).The hemostasis time of the observation group was shorter than that of the control group(P<0.05).After treatment,APTT and PT in the two groups were smaller than those before treatment,FIB was larger than that before treatment,while APTT and PT in the observation group were smaller than those in the control group,FIB was larger than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Hemabate combined with oxytocin is effective in the treatment of postpartum hemorrhage,which can improve the total effective rate of hemostasis,reduce the amount of bleeding within 24 hours after delivery,shorten the hemostasis time,improve the coagulation function index,and have fewer adverse reactions,with certain application advantages.