艾普拉唑钠与奥美拉唑钠治疗上消化道出血的疗效比较

Efficacy Comparison of Ilaprazole Sodium and Omeprazole Sodium in the Treatment of Upper Gastrointestinal Bleeding

目的比较艾普拉唑钠和奥美拉唑钠治疗上消化道出血的治疗效果。方法选取2021年5月-2022年5月永修县人民医院诊治的64例上消化道出血患者为研究对象,采用随机数字表法分为对照组和观察组,各32例。两组均给予阿莫西林胶囊,在此基础上,对照组采用注射用奥美拉唑钠,观察组采用注射用艾普拉唑钠,比较两组临床止血有效率、平均止血时间、出血量、再出血率、胃液pH值、血红蛋白水平、血细胞比容、不良反应发生率、治疗费用、住院时间。结果观察组止血有效率为93.75%,与对照组的96.88%比较,差异无统计学意义(P>0.05);观察组平均止血时间短于对照组,出血量少于对照组,再出血率低于对照组(P<0.05);观察组胃液pH值、血红蛋白水平、血细胞比容高于对照组(P<0.05);观察组不良反应发生率为9.38%,低于对照组的15.63%(P<0.05);观察组治疗费用高于对照组,住院时间短于对照组(P<0.05)。结论在上消化道出血治疗中,艾普拉唑钠和奥美拉唑钠均可获得良好的止血效果,但与奥美拉唑钠比较,艾普拉唑钠可缩短止血时间和住院时间,减少出血量,降低胃液pH值,改善血红蛋白水平、血细胞比容,降低不良反应发生率,但其治疗成本相对较高。

Objective To compare the therapeutic effect of ilaprazole sodium and omeprazole sodium in the treatment of upper gastrointestinal bleeding.Methods A total of 64 patients with upper gastrointestinal bleeding diagnosed and treated in Yongxiu County People's Hospital from May 2021 to May 2022 were selected as the research objects.They were divided into control group and observation group by random number table method,with 32 patients in each group.Both groups were given amoxicillin capsules.On this basis,the control group was treated with omeprazole sodium for injection,and the observation group was treated with ilaprazole sodium for injection.The clinical hemostasis efficiency,average hemostasis time,bleeding volume,rebleeding rate,gastric juice pH value,hemoglobin level,hematocrit,incidence of adverse reactions,treatment cost and hospitalization time were compared between the two groups.Results The total effective rate of hemostasis in the observation group was 93.75%,which was compared with 96.88%in the control group,the difference was not statistically significant(P>0.05).The average hemostasis time of the observation group was shorter than that of the control group,the amount of bleeding was less than that of the control group,and the rebleeding rate was lower than that of the control group(P<0.05).The pH value of gastric juice,hemoglobin level and hematocrit in the observation group were higher than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was 9.38%,which was lower than 15.63%in the control group(P<0.05).The treatment cost of the observation group was higher than that of the control group,and the hospitalization time was shorter than that of the control group(P<0.05).Conclusion In the treatment of upper gastrointestinal bleeding,both ilaprazole sodium and omeprazole sodium can achieve good hemostatic effect.However,compared with omeprazole sodium,ilaprazole sodium can shorten the hemostasis time and hospitalization time,reduce the amount of bleeding,reduce the pH value of gastric juice,improve hemoglobin level and hematocrit,and reduce the incidence of adverse reactions,but its treatment cost is relatively high.